TABLE 4

Bivariate Spearman correlation of biomarker levels and other diagnostic findings at baseline

ParameterMR-proANP pmol·L−1Copeptin pmol·L−1
Age yearsρ=0.20; p=0.03ρ=0.28; p=0.002
Body mass index kg·m−2ρ=−0.29; p=0.001ρ=−0.06; p=0.53
GFR mL·min−1ρ=−0.31; p<0.001ρ=−0.27; p=0.003
Serum creatinine µmol·L−1ρ=0.31; p<0.001ρ=0.35; p<0.001
mPAP mmHgρ=0.44; p<0.001ρ=0.07; p=0.47
PVR WUρ=0.51; p<0.001ρ=0.07; p=0.46
RAP mmHgρ=0.51; p<0.001ρ=0.26; p=0.008
CI·min−1·m−2ρ=−0.36; p<0.001ρ=−0.13; p=0.15
6MWD mρ=−0.26; p=0.03ρ=−0.27; p=0.02
LVEF %ρ=−0.30; p=0.002ρ=−0.03; p=0.74
TAPSE mmρ=−0.28; p=0.004ρ=−0.20; p=0.04

MR-proANP: mid-regional pro-atrial natriuretic peptide; GFR: glomerular filtration rate; mPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; RAP: right atrial pressure; CI: cardiac index; 6MWD: 6-min walk distance; LVEF: left ventricular ejection fraction; TAPSE: tricuspid annular plane systolic excursion.