Examined treatable traits, measurement instruments, cut-off values applied and appropriate evidence-based nonpharmacological interventions

Treatable traitMeasurement instrumentCut-off valuePossible (combinations of) intervention(s)
1Current smokingMedical historyPositive on historySimple advice, combination of behavioural treatment and pharmacotherapy [17]
2Activity-related dyspnoea [18]Medical Research Council dyspnoea scaleGrade ≥3exercise training, pulmonary rehabilitation [19]
3Frequent exacerbations [13]Medical history≥2 exacerbations or ≥1 hospitalisation past yearExacerbation action plan [20], pulmonary rehabilitation [19]
4Poor nutritional status [21]BMIBMI<21 or BMI>30 kg·m−2Nutritional support [22], dietary counselling and calorie restriction plus resistance exercise training [23]
5Severe fatigue [24]Checklist individual strength-fatigue≥36 pointsPulmonary rehabilitation [19]
6Depressed mood [25]Beck depression inventory≥4 pointsCognitive behavioural therapy [26], pulmonary rehabilitation [19]
7Poor exercise capacity [27]Six-minute walk test<70% predictedExercise training, pulmonary rehabilitation [19]
8Low habitual physical activity [27]Move monitor<5000 steps·day−1Exercise training plus physical activity counselling [28]
9Patient activation for self-management [29]Patient activation measureLevel 1–2Self-management program [30]