Patients | Estimated annual rate of decline | Baseline-adjusted estimates | |||

1 year | 2 years | 3 years | |||

FVC % pred based on as-observed (nonimputed) data^{#} | 30 | 4.2 (1.9–6.6); p=0.001 | 72.4 (68.3–76.5) | 68.2 (64.7–71.6) | 64.0 (59.6–68.3) |

FVC % pred including data imputed due to death^{¶} | 30 | 7.5 (3.3–11.7); p=0.001 | 72.0 (68.1–75.9) | 64.5 (59.4–69.7) | 57.0 (48.3–65.7) |

D_{LCO} % pred based on as-observed (nonimputed) data^{+} | 24 | 5.7 (3.1–8.4); p<0.001 | 45.0 (40.9–49.2) | 39.3 (34.5–44.2) | 33.6 (26.9–40.3) |

D_{LCO} % pred including data imputed due to death^{§} | 24 | 5.8 (3.4–8.1); p<0.001 | 45.0 (41.3–48.8) | 39.3 (35.1–43.5) | 33.5 (27.8–39.3) |

Data are presented as n or % (95% CI), unless otherwise stated. ^{#}: linear mixed model using random intercept and slope with unstructured covariance matrix; ^{¶}: linear mixed model using random intercept and slope with compound symmetry covariance matrix; six measurements (n=2 at 2 years and n=4 at 3 years) were imputed to 30% due to death; ^{+}: linear mixed model using random intercept and slope with Toeplitz covariance matrix; ^{§}: linear mixed model using random intercept and slope with Toeplitz covariance matrix; n=1 measurement at 3 years was imputed to 15% due to death.