TABLE 2

Secondary end-points

Baseline1 months3 monthsChange from baseline at 3 monthsp-value (Friedman's test)
Cough severity VASMedian 30.5 (9, 94)
Mean 38.8 (25.7)
24.0 (3, 88)
33.7 (25.2)
19.0 (0, 62)
19.8 (17.7)
−9.0 (−93, 20)
−18.1 (27.6)
0.009
Cough urge VASMedian 26.0 (8, 94)
Mean 38.7 (26.2)
26.0 (2, 83)
32.5 (23.3)
18.5 (0, 61)
22.2 (18.3)
−13.0 (−83, 42)
−15.7 (27.9)
0.066
LCQMedian 15.96 (5.07, 19.74)
Mean 14.63 (4.07)
17.6 (6.11, 20.75)
16.68 (3.41)
19.02 (14.93, 20.38)
18.23 (1.76)
1.85 (−1.17, 12.18)
3.47 (4.0)
0.006
KSQ_GHMedian 50.7 (23.8, 100)
Mean 52.93 (18.3)
61.9 (29.4, 100)
63.0 (18.1)
72.25 (39.9, 100)
69.63 (15.4)
16.3 (−13.8, 47.1)
17.5 (15.8)
0.001
KSQ_lungMedian 50.2 (29.0, 68.0)
Mean 52.0 (10.4)
52.6 (33.6, 77.1)
54.5 (12.0)
61.95 (41.6, 100)
62.5 (14.0)
6.5 (−1.3, 34.8)
10.7 (11.3)
0.001
KSQ_lung_GHMedian 58.1 (36.7, 74.7)
Mean 57.3 (9.1)
58.7 (41.9, 86.1)
61.9 (11.6)
66.25 (50.1, 91.5)
67.58 (10.4)
10.7 (−2.3, 26.8)
10.6 (8.3)
0.0001

Data are presented as median (range) and mean (sd). VAS: visual analogue scale; LCQ: Leicester cough questionnaire; KSQ: King's sarcoidosis questionnaire (presented as general health (GH), lung and combined lung-GH domains).