CTDPH# | Proximal CTEPH¶ | Distal CTEPH+ | ||||
p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | |
6MWD | <0.001* | 0.99 (0.99–1) | <0.001* | 0.99 (0.99–1) | <0.001* | 0.99 (0.99–1) |
TLCO % | 0.005* | 0.98 (0.97–0.99) | 0.07 | 0.98 (0.96–1) | <0.001* | 0.96 (0.95–0.98) |
Log NT-proBNP | <0.001* | 1.9 (1.4–2.6) | 0.003* | 2.9 (1.71–5.04) | <0.001* | 3.47 (1.8–6.5) |
Cardiac output | <0.001* | 0.71 (0.61–0.82) | 0.004* | 0.62 (0.45–0.86) | 0.02* | 0.71 (0.53–0.94) |
RAP | 0.002* | 1.05 (1.02–1.07) | 0.01* | 1.07 (1.01–1.12) | 0.01* | 1.1 (1–1.1) |
SvO2 | <0.001* | 0.96 (0.95–0.98) | 0.003* | 0.95 (0.92–0.98) | <0.001* | 0.94 (0.92–0.97) |
mPAP | 0.32 | 1.01 (0.99–1.02) | 0.35 | 1.01 (0.99–1.04) | 0.5 | 1.01 (0.99–1.03) |
PAWP | 0.24 | 1.02 (0.99–1.04) | 0.66 | 1.02 (0.94–1.1) | 0.43 | 1.03 (0.96–1.01) |
emPHasis-10 | 0.02* | 1.04 (1.01–1.08) | 0.4 | 1.02 (0.97–1.08) | 0.07 | 1.09 (0.99–1.19) |
HR: hazard ratio; 6MWD: 6-min walk distance; TLCO: transfer factor of the lung for carbon monoxide; NT-proBNP: N-terminal pro-brain natriuretic peptide; RAP: right atrial pressure; SvO2: mixed venous oxygen saturation; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary arterial wedge pressure. Note that, for some patients, data were unavailable for distinguishing whether the CTEPH was distal or proximal. #: n=232; ¶: n=142; +: n=97. *: p<0.05.