Ventilatory variables of patients with acute respiratory distress syndrome (ARDS) secondary to novel coronavirus disease (COVID-19) who developed pneumomediastinum/subcutaneous emphysema (n=23)

VariablesOn the first day of mechanical ventilationOn the day of P/SEp-value
Positive end-expiratory pressure cmH2O12 (8–15)9 (6–13)0.002
Peak airway pressure cmH2O30±529±50.08
Plateau airway pressure cmH2O24±522±40.045
PaCO2 mmHg54±1453±120.77
Compliance of the respiratory system mL·cmH2O−125 (22–34)33 (27–40)0.13
Minute ventilation L·min−18.4±1.28.9±2.10.13
Corrected minute ventilation L·min−111.5±412.1±4.10.45
PaO2/FIO2 mmHg108±33131±760.13
Tidal volume/ideal body weight mL·kg−16±0.96.7±1.70.008

Data are presented as median (interquartile range) or mean±sd, unless otherwise stated. P/SE: pneumomediastinum/subcutaneous emphysema; PaCO2: arterial carbon dioxide tension; PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction.