Baseline characteristics and outcomes in patients with acute respiratory distress syndrome (ARDS) secondary to novel coronavirus disease (COVID-19) with and without pneumomediastinum/subcutaneous emphysema (P/SE)

VariablesWithout P/SEWith P/SEp-value
Subjects n14623
Age years67 (59–71)64 (60–70)0.24
Male sex118 (80.8)15 (65)0.09
Body mass index kg·m−228 (26–31)27 (25–31)0.29
Diabetes mellitus23 (15.8)3 (13)0.74
Arterial hypertension79 (54.1)11 (47.8)0.58
COPD4 (2.7)0 (0)1
Positive end-expiratory pressure cmH2O12 (10–14)12 (8–15)0.72
Peak airway pressure cmH2O29±530±50.56
Plateau airway pressure cmH2O23±424±60.80
PaCO2 mmHg57±1653±150.26
Compliance of the respiratory system mL·cmH2O−127 (22–33)28 (22–36)0.55
Minute ventilation L·min−18.9±1.38.3±1.10.04
Corrected minute ventilation L·min−112.7 (9.4–15)9.9 (8.4–13.1)0.07
PaO2/FIO2 mmHg114 (86–153)105 (81–137)0.21
Tidal volume/ideal body weight mL·kg−15.9±0.86.1±0.90.23
Length of stay in intensive care unit9 (5–18)11 (6–21)0.44
Length of stay in hospital14 (8–23)18 (12–28)0.18
In-hospital mortality73 (50)13 (56.5)0.46

Data are presented as median (interquartile range), n (%) or mean±sd, unless otherwise stated. PaCO2: arterial carbon dioxide tension; PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction.