TABLE 2

Demographic, polysomnographic (PSG) and comorbidity data and statistical analyses between the best-performing (Q1) and worst-performing (Q4) quartiles based on lapses and sample entropy of reaction times in a psychomotor vigilance task

Male OSA patients#Female OSA patients
LapsesSample EntropyLapsesSample Entropy
Q1 (<4)Q4 (>21)Q1 (<0.105)Q4 (>0.656)Q1 (<9)Q4 (>51)Q1 (<0.163)Q4 (>0.800)
Demographic parameters
 Patients n8880828266596060
 Age years51.1 (40.7–61.7)56.9 (48.4–67.1)52.8 (40.5–65.3)55.4 (44.9–62.2)54.3 (44.7–60.3)58.8 (50.3–64.8)54.1 (45.1–62.3)55.9 (45.5–62.2)
 BMI kg·m−232.9 (28.7–37.8)34.7 (29.8–39.5)34.5 (30.9–40.4)33.7 (29.5–37.8)37.0 (32.3–44.4)36.0 (31.8–47.1)38.7 (32.5–45.8)36.0 (29.0–42.7)
Comorbidities
 COPD6 (6.8)8 (10.0)5 (6.1)5 (6.1)5 (7.6)8 (13.6)5 (8.3)6 (10.0)
 Hypertension26 (29.6)35 (43.8)32 (39.0)30 (36.6)22 (33.3)29 (49.2)22 (36.7)22 (36.7)
 Depression8 (9.1)13 (16.3)6 (7.3)13 (15.9)14 (21.2)15 (25.4)10 (16.7)14 (23.3)
 Smokers13 (14.8)13 (16.3)14 (17.1)12 (14.6)6 (9.1)10 (17.0)8 (13.3)9 (15.0)
 ESS score9 (6–15)10 (6–14)8 (5–12)10 (5–13)9 (6–12)13 (6–18)11 (6–15)9 (5–13)
PSG parameters
 Total sleep time h5.4 (4.8–6.1)4.9 (4.5–5.8)5.3 (4.7–6.1)5.2 (4.6–5.9)5.4 (6.0–4.7)5.6 (4.9–6.4)5.6 (5.0–6.2)5.7 (4.9–6.3)
 N1 %15.5 (10.6–23.8)14.1 (8.7–21.5)15.4 (9.3–22.1)14.7 (9.6–25.7)7.9 (5.7–10.8)8.1 (5.8–12.8)8.0 (5.6–13.3)8.9 (6.0–14.4)
 N2 %47.3 (42.3–52.9)49.5 (42.6–57.9)48.2 (42.2–56.1)45.8 (39.6–54.1)47.1 (41.4–53.4)49.0 (40.3–61.2)47.3 (41.5–53.4)49.2 (40.4–53.0)
 N3 %16.2 (7.4–23.1)14.9 (5.0–24.2)14.6 (7.7–23.8)15.1 (9.4–23.4)24.2 (17.3–29.9)21.6 (12.0–29.3)23.0 (17.4–29.3)20.6 (15.2–29.4)
 REM %18.0 (13.7–22.4)17.0 (12.9–20.6)18.8 (14.7–22.4)15.8 (11.6–22.8)18.5 (12.9–23.3)19.1 (12.9–22.5)19.0 (13.0–21.8)19.2 (12.1–24.8)
 AI events·h−133.5 (22.4–46.8)31.6 (22.1–45.6)31.5 (19.5–42.9)35.1 (23.1–47.2)21.3 (30.4–16.1)24.3 (15.5–33.8)23.1 (16.0–32.0)22.7 (18.3–32.4)
 AHI events·h−129.8 (13.4–49.2)28.6 (19.9–44.3)25.0 (15.3–42.3)28.8 (18.9–53.8)16.0 (9.3–29.7)15.8 (10.1–37.7)17.6 (10.1–27.2)15.0 (8.9–31.0)
 ODI events·h−120.4 (6.7–32.9)21.0 (9.9–37.4)16.8 (7.5–30.1)20.0 (8.3–36.6)11.5 (5.2–26.8)13.3 (5.6–25.6)12.5 (5.1–24.6)9.3 (4.0–21.6)
 t90% min6.8 (1.3–46.8)15.6 (1.7–98.2)12.4 (1.4–44.7)8.9 (0.8–50.4)4.6 (0.8–32.8)11.5 (1.0–63.5)4.3 (0.5–42.8)3.4 (0.3–45.6)
 mDD %4.9 (4.1–7.4)5.3 (4.4–7.5)5.6 (4.1–8.0)5.1 (4.1–6.6)5.0 (4.1–6.4)5.1 (4.3–6.0)4.7 (4.0–6.2)4.9 (4.1–6.0)

Data are presented as median (interquartile range) or n (%), unless otherwise stated. OSA: obstructive sleep apnoea; BMI: body mass index; COPD: chronic obstructive pulmonary disease; ESS: Epworth Sleepiness Scale; N1–N3: non-rapid eye movement sleep stages 1–3; REM: rapid eye movement sleep; AI: arousal index; AHI: apnoea–hypopnoea index; ODI: oxygen desaturation index; t90%: time spent under 90% oxygenation; mDD: median desaturation depth. #: n=327; : n=240. Bolded values indicate statistical difference (p<0.05) between Q1 and Q4 in the corresponding sex. Wilcoxon rank sum and Chi-squared tests were used where appropriate.