TABLE 1

Expression data for top up- and downregulated genes in COPD compared to normal basal cells and genes involved in epithelial/epidermal differentiation and tissue development

Gene symbolCOPDNormalFold changep-value
Top-20 downregulated genes in COPD
 HOXA1#1.51±0.703.67±0.50−4.471.8×10−6
 TENM26.98±0.458.13±0.28−2.213.3×10−6
 SLC2A122.93±0.574.61±0.65−3.192.0×10−5
 VGLL1#5.06±0.616.67±0.57−3.054.7×10−5
 ARHGAP401.75±0.513.21±0.72−2.761.0×10−4
 CLIC35.23±0.596.48±0.66−2.382.0×10−4
 HOXB2#1.89±0.313.29±0.93−2.642.0×10−4
 IL36RN2.76±0.453.76±0.69−2.003.0×10−4
 PADI13.31±0.634.76±0.76−2.735.0×10−4
 MFAP54.49±0.686.31±0.85−3.535.0×10−4
 ATP12A5.06±1.267.23±1.40−4.488.0×10−4
 FAM46C2.21±0.403.23±0.60−2.029.0×10−4
 MAL4.20±0.736.31±1.75−4.321.0×10−3
 KLK54.47±0.775.90±0.84−2.681.1×10−3
 HEPHL11.25±0.312.59±1.16−2.531.1×10−3
 LGALS9B4.86±0.626.43±0.79−2.971.2×10−3
 ELF53.84±0.574.92±0.93−2.122.2×10−3
 KLK77.42±0.508.45±0.93−2.052.4×10−3
 SCNN1G3.45±0.724.65±0.60−2.312.7×10−3
 UPK1A1.96±0.553.94±1.93−3.962.8×10−3
 IVL3.92±1.035.1±1.1−2.270.0093
 KRTDAP#2.47±0.63.59±1.57−2.170.0114
 S100A71.82±0.893.17±1.18−2.550.0186
 KRT241.66±0.943.28±1.15−3.060.0241
DSG12.64±1.654.32±1.96−3.210.0411
Top-10 upregulated genes in COPD
 HIST3H2BB4.92±0.413.78±0.382.212.1×10−6
 CLGN3.83±0.802.19±0.503.123.0×10−4
 HIST1H3J5.33±0.444.08±0.582.393.0×10−4
 HIST1H2AB6.02±0.614.51±0.512.844.0×10−4
 ANXA106.24±1.334.24±1.163.994.0×10−3
 HIST1H3H2.70±0.261.62±0.832.136.0×10−3
 CHAC16.73±1.324.83±0.453.721.2×10−2
 CCNE25.67±0.754.62±0.292.071.6×10−2
 GTF2H21.75±1.090.65±0.622.153.3×10−2
 ADAMTSL34.25±0.953.15±0.842.143.6×10−2
Control genes
 G3PDH4.11±2.114.21±0.12−1.070.2273
 KRT510.13±0.1210.36±0.17−1.100.0155

Data are presented as log2mean±sd unless otherwise stated. #: involved in tissue development; : involved in epithelial/epidermal differentiation.