CPFE | CPFE-LC | p-value | |
Patients | 204 | 26 | |
Age at diagnosis of CPFE years (95% CI) | 68±9.1 (67–70) | 66±7.1 (63–69) | 0.18 |
Male | 155 (76) | 18 (69) | 0.45 |
Smoking status | 0.31 | ||
Active | 12 (5.5) | 2 (8) | |
Former | 192 (94) | 24 (92) | |
Smoker pack-years (95% CI) | 56±24.6 (46–66) | 50±28.3 (46–54) | 0.08 |
Finger clubbing | 40 (20) | 7 (27) | 0.39 |
LABA use | 117 (57) | 11 (42) | 0.15 |
Systemic steroid | 70 (34) | 10 (38) | 0.68 |
Immunosuppressive agents | 15 (7.4) | 1 (4) | 0.51 |
Home oxygen | 155 (76) | 16 (62) | 0.11 |
RVSP mmHg | 49 (39–63) | 49 (32–66.5) | 0.40 |
PFT findings | |||
TLC % pred (95% CI) | 84.1±16.7 (81–87) | 91.2±16.1 (82–100) | 0.12 |
FVC % pred (95% CI) | 80.8±18.5 (78–84) | 85.8±18.2 (78–94) | 0.22 |
FEV1 % pred (95% CI) | 75.8±18.9 (73–79) | 76.7±16.3 (70–84) | 0.83 |
FEV1/FVC (95% CI) | 73.5±11.5 (72–75) | 71±12.3 (66–76) | 0.31 |
DLCO % pred (95% CI) | 42.9±16.9 (40–45) | 49.6±16.9 (42–58) | 0.09 |
PFT pattern# | 0.86 | ||
Normal | 9 (4) | 1 (4) | |
Obstructive | 46 (23) | 7 (30) | |
Restrictive | 63 (31) | 5 (22) | |
Isolated low DLCO | 60 (29) | 6 (26) | |
Nonspecific | 9 (4) | 3 (13) | |
Mixed | 1 (0.5) | 1 (4) | |
Radiological features | |||
Presence of honeycombing | 74 (36) | 9 (35) | 1.0 |
Distribution of emphysema | 0.90 | ||
Centrilobular | 81 (40) | 9 (35) | |
Subpleural | 32 (16) | 3 (12) | |
Mixed | 91 (45) | 8 (31) | |
Lung transplantation | 8 (4) | 0 (0) | 0.88 |
All-cause mortality | 103 (50) | 21 (81) | 0.003 |
Data are presented as n, mean±sd, n (%) or median (interquartile range), unless otherwise stated. Bold type represents statistical significance. LABA: long-acting β2-agonist; RVSP: right ventricular systolic pressure; PFT: pulmonary function test; TLC: total lung capacity; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide. #: CPFE n=188, CPFE-LC n=23.