TABLE 3

Combined pulmonary fibrosis and emphysema (CPFE) univariable and multivariable Cox regression predictors of all-cause mortality for the whole cohort

Univariable HR (95% CI)p-valueMultivariable# HR (95% CI)p-value
Age at CPFE diagnosis years1.04 (1.02–1.06)<0.00011.04 (1.02–1.06)<0.0001
Male sex %1.25 (0.83–1.90)0.28
Smoking pack-years1.00 (0.99–1.01)0.22
Finger clubbing1.23 (0.82–1.86)0.32
Home oxygen use1.98 (1.21–3.28)0.0042.09 (1.24–3.51)0.005
RVSP mmHg1.02 (1.01–1.03)<0.00011.02 (1.01–1.03)<0.0001
FVC % pred0.99 (0.99–1.01)0.78
FEV1 % pred0.99 (0.99–1.01)0.89
DLCO % pred0.97 (0.96–0.99)<0.00050.98 (0.96–0.99)0.0011
Presence of honeycombing2.07 (1.44–2.97)0.00012.18 (1.49–3.19)<0.001
Lung cancer diagnosis1.69 (1.05–2.71)0.0392.25 (1.36–3.72)0.0015

n=230. Bold type represents statistical significance. HR: hazard ratio; RVSP: right ventricular systolic pressure; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide. #: adjusted for age, sex, pack-years, FVC % pred and presence of honeycombing; : unit HRs for linear predictors.