Combined pulmonary fibrosis and emphysema (CPFE) univariable and multivariable Cox regression predictors of all-cause mortality for the whole cohort
| Univariable HR (95% CI) | p-value | Multivariable# HR (95% CI) | p-value | |
| Age at CPFE diagnosis years¶ | 1.04 (1.02–1.06) | <0.0001 | 1.04 (1.02–1.06) | <0.0001 |
| Male sex % | 1.25 (0.83–1.90) | 0.28 | ||
| Smoking pack-years¶ | 1.00 (0.99–1.01) | 0.22 | ||
| Finger clubbing | 1.23 (0.82–1.86) | 0.32 | ||
| Home oxygen use | 1.98 (1.21–3.28) | 0.004 | 2.09 (1.24–3.51) | 0.005 |
| RVSP mmHg¶ | 1.02 (1.01–1.03) | <0.0001 | 1.02 (1.01–1.03) | <0.0001 |
| FVC % pred¶ | 0.99 (0.99–1.01) | 0.78 | ||
| FEV1 % pred¶ | 0.99 (0.99–1.01) | 0.89 | ||
| DLCO % pred¶ | 0.97 (0.96–0.99) | <0.0005 | 0.98 (0.96–0.99) | 0.0011 |
| Presence of honeycombing | 2.07 (1.44–2.97) | 0.0001 | 2.18 (1.49–3.19) | <0.001 |
| Lung cancer diagnosis | 1.69 (1.05–2.71) | 0.039 | 2.25 (1.36–3.72) | 0.0015 |
n=230. Bold type represents statistical significance. HR: hazard ratio; RVSP: right ventricular systolic pressure; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide. #: adjusted for age, sex, pack-years, FVC % pred and presence of honeycombing; ¶: unit HRs for linear predictors.