Stratified analysis of maternal exacerbations on adverse perinatal outcomes by asthma treatment dispensed 24 months preconception
| SABA only | ICS monotherapy/other mild asthma treatment | ICS/LABA therapy | |||||||
| No exacerbation | Exacerbation | aOR# (95% CI) | No exacerbation | Exacerbation | aOR# (95% CI) | No exacerbation | Exacerbation | aOR# (95% CI) | |
| Subjects n | 3175 | 102 | 11 048 | 286 | 9783 | 592 | |||
| Birthweight categories | |||||||||
| ≤2499 g | 109 (3.4) | 2 (2.0) | 0.69 (0.16–2.90) | 370 (3.3) | 10 (3.5) | 0.81 (0.40–1.67) | 426 (4.4) | 38 (6.4) | 1.54 (1.05–2.24) |
| 2500–2999 g | 354 (11.2) | 17 (16.7) | 1.72 (0.99–3.00) | 1166 (10.6) | 38 (13.3) | 1.09 (0.74–1.59) | 1121 (11.5) | 100 (16.9) | 1.65 (1.29–2.10) |
| 3000–3999 g¶ | 2043 (64.4) | 59 (57.8) | Ref. | 7351 (66.5) | 193 (67.5) | Ref. | 6597 (67.4) | 362 (61.2) | Ref. |
| ≥4000 g | 662 (20.9) | 24 (23.5) | 1.19 (0.71–2.00) | 2178 (19.7) | 45 (15.7) | 0.83 (0.58–1.17) | 1618 (16.5) | 91 (15.4) | 1.04 (0.81–1.34) |
| Missing | 7 (0.2) | 0 | 19 (0.2) | 0 | 22 (0.2) | 1 (0.2) | |||
| Preterm birth | |||||||||
| Yes | 196 (6.2) | 9 (8.8) | 1.50 (0.76–3.00) | 625 (5.7) | 12 (4.2) | 0.62 (0.33–1.17) | 586 (6.0) | 47 (7.9) | 1.28 (0.92–1.79) |
| Missing | 1 (0.03) | 0 | 6 (0.05) | 0 | 5 (0.05) | 0 | |||
| Small for gestational age | |||||||||
| Yes | 63 (2.0) | 2 (2.0) | 1.08 (0.26–4.5) | 274 (2.5) | 10 (3.5) | 1.04 (0.50–2.17) | 311 (3.2) | 31 (5.2) | 1.74 (1.18–2.57) |
| Missing | 8 (0.2) | 0 | 25 (0.2) | 0 | 26 (0.3) | 1 (0.2) | |||
| Mode of Delivery | |||||||||
| Vaginal/instrumental | 2552 (80.4) | 81 (79.4) | Ref. | 8932 (80.8) | 219 (76.6) | Ref. | 7689 (78.6) | 402 (67.9) | Ref. |
| Elective caesarean section | 254 (8.0) | 10 (9.8) | 1.26 (0.64–2.47) | 905 (8.2) | 29 (10.1) | 1.26 (0.84–1.89) | 899 (9.2) | 84 (14.2) | 1.69 (1.30–2.20) |
| Emergency caesarean section | 330 (10.4) | 9 (8.8) | 0.87 (0.43–1.76) | 1133 (10.3) | 33 (11.5) | 1.09 (0.74–1.61) | 1057 (11.0) | 93 (15.7) | 1.62 (1.26–2.08) |
| Unknown caesarean section | 39 (1.2) | 2 (2.0) | 114 (1.0) | 5 (1.7) | 119 (1.2) | 13 (2.2) | |||
Data are presented as n (%), unless otherwise stated. SABA: short-acting β-agonists; ICS: inhaled corticosteroids; LABA: long-acting β-agonist. #: adjusted for maternal smoking, obesity, education, country of birth, parity and depression/anxiety, and infant sex; ¶: approximately mean±1sd in population.