Diagnostic accuracy of nasal nitric oxide (nNO), transmission electron microscopy (TEM) and genetic evaluation for diagnosis of primary ciliary dyskinesia
| nNO <77 nL·min−1 | nNO <30 nL·min−1 | TEM | WES | |
| All subjects, including unresolved diagnosis (n=57) | 48 | 48 | 41 | 48 |
| Sensitivity (95% CI) | 100 (89.1–100) | 93.8 (79.2–99.2) | 62.2 (44.8–77.5) | 94.4 (81.3–99.3) |
| Specificity (95% CI) | 50.0 (21.1–78.9) | 75.0 (42.8–94.5) | 85.7 (57.2–98.2) | 100 (73.5–100) |
| ROC area (95% CI) | 0.75 (0.60–0.90) | 0.84 (0.71–0.98) | 0.74 (0.62–0.86) | 0.97 (0.93–1.0) |
WES: untargeted whole-exome sequencing; ROC: receiver operating characteristic.