Comparison of risk stratification algorithms calculated based on hsTnI and hsTnT
| Risk stratification algorithm | Troponin assay and cut-off value | Prevalence | In-hospital adverse outcome | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | LR+ | OR (95% CI) | NRI |
| Modified FAST score ≥3 points | hsTnT ≥14 pg·mL−1 | 21.8% | 12.0% | 54.5% (32.7–74.9) | 79.9% (75.7–83.5) | 12.0% (7.0–19.8) | 97.2% (94.9–98.5) | 2.7 | 4.76 (1.99–11.37) | 0.06 (SE 0.09), p=0.51 |
| hsTnI >16 pg·mL−1 | 25.1% | 12.2% | 63.6% (40.8–82.0) | 76.9% (72.6–80.7) | 12.2% (7.4–19.4) | 97.7% (95.5–98.8) | 2.8 | 5.82 (2.38–14.27) | ||
| ESC 2019 intermediate-high-risk# | hsTnT ≥14 pg·mL−1 | 32.2% | 8.8% | 59.1% (36.7–78.5) | 69.1% (64.5–73.4) | 8.8% (5.2–14.4) | 97.1% (94.6–98.5) | 1.9 | 3.23 (1.35–7.74) | 0.03 (SE 0.07), p=0.68 |
| hsTnI >16 pg·mL−1 | 29.6% | 9.6% | 59.1% (36.7–78.5) | 71.9% (67.3–76.0) | 9.6% (5.7–15.7) | 97.2% (94.8–98.5) | 2.1 | 3.69 (1.54–8.85) |
HsTnI: high-sensitivity troponin I; hsTnT: high-sensitivity troponin T; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; LR+: positive likelihood ratio; OR: odds ratio; NRI: net reclassification improvement; SE: standard error; ESC: European Society of Cardiology. #: Compared to ESC 2019 low/intermediate-low risk.