NAME | Direction | SIZE | ES | NES | FDR q-value | Leading edge |
KOBAYASHI EGFR SIGNALING_24HR_DN | Upregulated | 244 | 0.74 | 2.23 | 0 | tags: 74%, list: 16%, signal: 88% |
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | Upregulated | 137 | 0.74 | 2.13 | 0 | tags: 84%, list: 18%, signal: 102% |
SOTIRIOU BREAST CANCER GRADE 1_VS_ 3 UP | Upregulated | 146 | 0.74 | 2.13 | 0 | tags: 85%, list: 18%, signal: 103% |
MANALO HYPOXIA DN | Upregulated | 282 | 0.69 | 2.11 | 0 | tags: 65%, list: 15%, signal: 75% |
DUTERTRE ESTRADIOL_RESPONSE_24HR UP | Upregulated | 316 | 0.68 | 2.10 | 0 | tags: 68%, list: 15%, signal: 80% |
BLUM RESPONSE TO_SALIRASIB_DN | Upregulated | 340 | 0.66 | 2.06 | 0 | tags: 70%, list: 18%, signal: 85% |
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR | Upregulated | 82 | 0.77 | 2.06 | 0 | tags: 78%, list: 14%, signal: 91% |
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR | Upregulated | 123 | 0.73 | 2.04 | 0 | tags: 77%, list: 17%, signal: 93% |
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | Upregulated | 173 | 0.69 | 2.02 | 0 | tags: 73%, list: 18%, signal: 88% |
FOURNIER ACINAR_DEVELOPMENT_LATE_2 | Upregulated | 270 | 0.66 | 2.01 | 0 | tags: 64%, list: 16%, signal: 76% |
TIEN INTESTINE PROBIOTICS_24HR_DN | Downregulated | 213 | −0.69 | −2.11 | 0 | tags: 82%, list: 21%, signal: 103% |
BOSCO EPITHELIAL DIFFERENTIATION MODULE | Downregulated | 69 | −0.75 | −2.01 | 2.57×10−4 | tags: 74%, list: 18%, signal: 90% |
KEGG RIBOSOME | Downregulated | 88 | −0.73 | −2.03 | 3.85×10−4 | tags: 88%, list: 23%, signal: 114% |
REACTOME SRP_DEPENDENT_COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Downregulated | 126 | −0.68 | −1.98 | 4.69×10−4 | tags: 83%, list: 23%, signal: 107% |
REACTOME PEPTIDE_CHAIN_ELONGATION | Downregulated | 102 | −0.72 | −1.98 | 5.86×10−4 | tags: 87%, list: 23%, signal: 113% |
RICKMAN HEAD_AND_NECK_CANCER_E | Downregulated | 87 | −0.71 | −1.94 | 0.00184 | tags: 71%, list: 17%, signal: 85% |
REACTOME 3_UTR_MEDIATED_TRANSLATIONAL REGULATION | Downregulated | 123 | −0.66 | −1.93 | 0.00203 | tags: 71%, list: 19%, signal: 87% |
REACTOME TRANSLATION | Downregulated | 165 | −0.63 | −1.88 | 0.00587 | tags: 66%, list: 19%, signal: 82% |
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE_EXON JUNCTION_COMPLEX | Downregulated | 123 | −0.64 | −1.87 | 0.00609 | tags: 80%, list: 23%, signal: 103% |
HOLLERN EMT_BREAST_TUMOR_DN | Downregulated | 95 | −0.65 | −1.82 | 0.01532 | tags: 51%, list: 12%, signal: 57% |
143 pathways were significantly (q<0.05) enriched in B-HBECs and 20 were enriched in the N-HBECs (top 10 shown ranked on q-value and then ES). Size indicates the number of genes in the gene set after filtering out those not in the expression dataset.
N-HBEC: normal human bronchial epithelial cell; B-HBEC: BMI-1-expressing human bronchial epithelial cells; ES: enrichment score for the gene set, which is the degree that the gene set is over-represented at the top or bottom of the ranked list of genes in the expression dataset; NES: normalised enrichment score; FDR q-value: false discovery rate adjusted p-value, which is the estimated probability that the NES represents a false positive; leading edge subset: subset of members that contribute the most to the ES; tags: percentage of genes contributing to the ES.