DLCO ≤20% pred | DLCO >20% pred | p-value | |
Subjects n | 34 | 87 | |
Age years | 65.5±6.8 | 64.4±15.2 | 0.69 |
BMI kg·m−2 | 25.46±9.8 | 24.62±9.8 | 0.81 |
Sex % | 0.03 | ||
Male | 41.2 | 62.8 | |
Female | 58.8 | 37.2 | |
Comorbidities % | |||
α1-antitrypsin-deficiency | 5.9 | 3.5 | 0.15 |
Cardiovascular disease | 26.5 | 18.6 | 0.34 |
Pulmonary hypertension | 8.8 | 9.3 | 0.94 |
Atrial fibrillation | 5.9 | 8.1 | 0.67 |
Arterial hypertension | 35.3 | 55.8 | 0.04 |
Osteoporosis | 5.9 | 9.3 | 0.54 |
Diabetes mellitus type II | 2.9 | 4.7 | 0.67 |
Lung cancer | 0.0 | 1.2 | 0.17 |
Active tumours | 0.0 | 2.3 | 0.53 |
Others | 20.6 | 26.7 | 0.77 |
Emphysema score in target lobe# | 42.9±13.3 | 45.8±10.7 | 0.31 |
Heterogeneity index between target and adjacent lobe# | 22.7±9.6 | 21.0±12.5 | 0.45 |
Lung function test at baseline | |||
FEV1 % pred | 30.0±9.5 | 33.0±9.9 | 0.11 |
RV % pred | 261.1±49.6 | 251.4±52.3 | 0.51 |
DLCO % pred | 16.1±3.4 | 34.7±11.8 | <0.001 |
6MWD m | 254.7±92.8 | 276.6±115.9 | 0.94 |
mMRC points | 3.4±0.7 | 3.0±0.9 | 0.25 |
SGRQ points | 60.7±12.0 | 59.6±11.9 | 0.98 |
Data are presented as mean±sd unless otherwise stated. DLCO: diffusing capacity of the lung for carbon monoxide; BMI: body mass index; FEV1: forced expiratory volume in 1 s; RV: residual volume; 6MWD: 6-min walk distance; mMRC: Medical Research Council dyspnoea; SGRQ: St George's Respiratory Questionnaire. #: software automated quantification of emphysema destruction (−950 Hounsfield units). Bold indicates statistical significance.