Genotype data of patients with community-acquired pneumonia (CAP)
| Patients n | Genotype frequencies (%) | p-value OR (95% CI) | |||||
| Genotype comparisons | Allele comparisons | ||||||
| CC | CT | TT | Recessive model: CC versus TC+TT | Additive model | |||
| rs4957796 | |||||||
| CAP | 960 | 29 (52.7) | 243 (46.8) | 688 (49.8) | 0.583 | 0.51 | 0.502 |
| Control | 996 | 26 (47.3) | 276 (53.2) | 694 (50.2) | 1.16 (0.68–1.99) | 0.94 (0.80–1.12) | 0.94 (0.80–1.12) |
| Dead 28 days | 57 | 2 (6.9) | 11 (4.5) | 44 (6.4) | 0.688 | 0.44 | 0.446 |
| Alive 28 days | 903 | 27 (93.1) | 232 (95.5) | 644 (93.6) | 1.18 (0.27–5.09) | 0.81 (0.47–1.40) | 0.81 (0.46–1.41) |
| Dead 90 days | 76 | 2 (6.9) | 15 (6.2) | 59 (8.6) | 1.000 | 0.26 | 0.262 |
| Alive 90 days | 884 | 27 (93.1) | 228 (93.8) | 629 (91.4) | 0.86 (0.20–3.68) | 0.76 (0.47–1.24) | 0.75 (0.46–1.24) |
| ARDS | 64 | 3 (10.3) | 15 (6.2) | 46 (6.7) | 0.435 | 0.82 | 0.814 |
| No ARDS | 896 | 26 (89.7) | 228 (93.8) | 642 (93.3) | 1.65 (0.48–5.59) | 1.06 (0.66–1.70) | 1.06 (0.65–1.72) |
| SS/SSh | 313 | 14 (48.3) | 79 (32.5) | 220 (32.0) | 0.068 | 0.25 | 0.235 |
| No SS/SSh | 647 | 15 (51.7) | 164 (67.5) | 468 (68.0) | 1.97 (0.94–4.14) | 1.16 (0.90–1.50) | 1.17 (0.90–1.51) |
| Sepsis | 765 | 27 (93.1) | 192 (79.0) | 546 (79.4) | 0.041 | 0.34 | 0.338 |
| No sepsis | 195 | 2 (6.9) | 51 (21.0) | 142 (20.6) | 3.53 (0.83–15.00) | 1.16 (0.85–1.58) | 1.17 (0.85–1.60) |
| ICU | 338 | 9 (31.0) | 82 (33.7) | 247 (35.9) | 0.633 | 0.44 | 0.432 |
| No ICU | 622 | 20 (69.0) | 161 (66.3) | 441 (64.1) | 0.82 (0.37–1.83) | 0.90 (0.70–1.17) | 0.90 (0.69–1.17) |
| ICU dead 28 days# | 44 | 1 (11.1) | 6 (7.3) | 37 (15.0) | 1.000 | 0.093 | 0.106 |
| ICU alive 28 days# | 294 | 8 (88.9) | 76 (92.7) | 210 (85.0) | 0.81 (0.10–6.81) | 0.55 (0.26–1.16) | 0.54 (0.25–1.15) |
| ICU dead 90 days# | 62 | 1 (11.1) | 10 (12.2) | 51 (20.6) | 1.000 | 0.068 | 0.076 |
| ICU alive 90 days# | 276 | 8 (88.9) | 72 (87.8) | 196 (79.4) | 0.55 (0.07–4.47) | 0.57 (0.31–1.08) | 0.57 (0.30–1.07) |
| rs62375529 | |||||||
| CAP | 960 | 23 (45.1) | 214 (48.2) | 723 (49.5) | 0.564 | 0.47 | 0.462 |
| Controls | 996 | 28 (54.9) | 230 (51.8) | 738 (50.5) | 0.85 (0.49–1.48) | 0.94 (0.79–1.12) | 0.93 (0.78–1.12) |
| Dead 28 days | 57 | 4 (17.4) | 8 (3.7) | 45 (6.2) | 0.042 | 0.88 | 0.874 |
| Alive 28 days | 903 | 19 (82.6) | 206 (96.3) | 678 (93.8) | 3.51 (1.15–10.7) | 1.04 (0.61–1.78) | 1.05 (0.61–1.80) |
| Dead 90 days | 76 | 4 (17.4) | 11 (5.1) | 61 (8.4) | 0.101 | 0.70 | 0.696 |
| Alive 90 days | 884 | 19 (82.6) | 203 (94.9) | 662 (91.6) | 2.53 (0.84–7.63) | 0.91 (0.56–1.48) | 0.91 (0.55–1.49) |
| ARDS | 64 | 2 (8.7) | 13 (6.1) | 49 (6.8) | 0.662 | 0.93 | 0.929 |
| No ARDS | 896 | 21 (91.3) | 201 (93.9) | 674 (93.2) | 1.34 (0.31–5.86) | 0.98 (0.58–1.54) | 0.98 (0.58–1.66) |
| SS/SSh | 313 | 14 (60.9) | 66 (30.8) | 233 (32.2) | 0.003¶ | 0.2 | 0.189 |
| No SS/SSh | 647 | 9 (39.1) | 148 (69.2) | 490 (67.8) | 3.32 (1.42–7.76) | 1.19 (0.91–1.56) | 1.20 (0.91–1.58) |
| Sepsis | 765 | 22 (95.7) | 165 (77.1) | 578 (79.9) | 0.025 | 0.77 | 0.764 |
| No sepsis | 195 | 1 (4.3) | 49 (22.9) | 145 (20.1) | 5.74 (0.77–42.90) | 1.05 (0.76–1.45) | 1.05 (0.76–1.46) |
| ICU | 338 | 9 (39.1) | 68 (31.8) | 261 (36.1) | 0.690 | 0.45 | 0.439 |
| No ICU | 622 | 14 (60.9) | 146 (68.2) | 462 (63.9) | 1.19 (0.51–2.77) | 0.90 (0.69–1.18) | 0.90 (0.68–1.18) |
| ICU dead 28 days | 44 | 2 (22.2) | 5 (7.4) | 37 (14.2) | 0.331 | 0.46 | 0.451 |
| ICU alive 28 days | 224 | 7 (77.8) | 63 (92.6) | 224 (85.8) | 1.95 (0.39–9.71) | 0.77 (0.38–1.56) | 0.76 (0.36–1.57) |
| ICU dead 90 days | 62 | 2 (22.2) | 8 (11.8) | 52 (19.9) | 0.672 | 0.27 | 0.260 |
| ICU alive 90 days | 276 | 7 (77.8) | 60 (88.2) | 209 (80.1) | 1.28 (0.26–6.32) | 0.71 (0.38–1.33) | 0.69 (0.36–1.32) |
Bivariate and multivariate analyses were performed using SPSS (version 15.0; SPSS, Inc., Chicago, IL, USA). The mean±sd age of the patients and controls was 61.8±17.7 and 44.3±19.3 years, respectively; 620 (66%) patients and 435 controls (52%) were male. Genotype distribution of both single-nucleotide polymorphisms did not differ significantly under conditions of Hardy–Weinberg equilibrium in the control group (p=0.444 for rs4957796, p=0.746 for rs62375529). Data are presented as n (%), unless otherwise stated. ARDS: acute respiratory distress syndrome; SS/SSh: severe sepsis/septic shock; ICU: intensive care unit; ICU dead 28/90 days: patients admitted to the ICU who died at 28/90 days; ICU alive 28/90 days: patients admitted to the ICU who survived at 28/90 days #: p-value for the bivariate comparison calculated with the Chi-squared test. ¶: after adjustment for age, sex, comorbidities and admitting hospital, the rs62375529 FER variant remains significantly associated with severe sepsis risk (OR=5.17; 95% CI 1.963–13.68, p=0.001), p-value for the multivariate analysis calculated with binary logistic regression.