TABLE 1

Genotype data of patients with community-acquired pneumonia (CAP)

Patients nGenotype frequencies (%)p-value
OR (95% CI)
Genotype comparisonsAllele comparisons
CCCTTTRecessive model: CC versus TC+TTAdditive model
rs4957796
 CAP96029 (52.7)243 (46.8)688 (49.8)0.5830.510.502
 Control99626 (47.3)276 (53.2)694 (50.2)1.16 (0.68–1.99)0.94 (0.80–1.12)0.94 (0.80–1.12)
 Dead 28 days572 (6.9)11 (4.5)44 (6.4)0.6880.440.446
 Alive 28 days90327 (93.1)232 (95.5)644 (93.6)1.18 (0.27–5.09)0.81 (0.47–1.40)0.81 (0.46–1.41)
 Dead 90 days762 (6.9)15 (6.2)59 (8.6)1.0000.260.262
 Alive 90 days88427 (93.1)228 (93.8)629 (91.4)0.86 (0.20–3.68)0.76 (0.47–1.24)0.75 (0.46–1.24)
 ARDS643 (10.3)15 (6.2)46 (6.7)0.4350.820.814
 No ARDS89626 (89.7)228 (93.8)642 (93.3)1.65 (0.48–5.59)1.06 (0.66–1.70)1.06 (0.65–1.72)
 SS/SSh31314 (48.3)79 (32.5)220 (32.0)0.0680.250.235
 No SS/SSh64715 (51.7)164 (67.5)468 (68.0)1.97 (0.94–4.14)1.16 (0.90–1.50)1.17 (0.90–1.51)
 Sepsis76527 (93.1)192 (79.0)546 (79.4)0.0410.340.338
 No sepsis1952 (6.9)51 (21.0)142 (20.6)3.53 (0.83–15.00)1.16 (0.85–1.58)1.17 (0.85–1.60)
 ICU3389 (31.0)82 (33.7)247 (35.9)0.6330.440.432
 No ICU62220 (69.0)161 (66.3)441 (64.1)0.82 (0.37–1.83)0.90 (0.70–1.17)0.90 (0.69–1.17)
 ICU dead 28 days#441 (11.1)6 (7.3)37 (15.0)1.0000.0930.106
 ICU alive 28 days#2948 (88.9)76 (92.7)210 (85.0)0.81 (0.10–6.81)0.55 (0.26–1.16)0.54 (0.25–1.15)
 ICU dead 90 days#621 (11.1)10 (12.2)51 (20.6)1.0000.0680.076
 ICU alive 90 days#2768 (88.9)72 (87.8)196 (79.4)0.55 (0.07–4.47)0.57 (0.31–1.08)0.57 (0.30–1.07)
rs62375529
 CAP96023 (45.1)214 (48.2)723 (49.5)0.5640.470.462
 Controls99628 (54.9)230 (51.8)738 (50.5)0.85 (0.49–1.48)0.94 (0.79–1.12)0.93 (0.78–1.12)
 Dead 28 days574 (17.4)8 (3.7)45 (6.2)0.0420.880.874
 Alive 28 days90319 (82.6)206 (96.3)678 (93.8)3.51 (1.15–10.7)1.04 (0.61–1.78)1.05 (0.61–1.80)
 Dead 90 days764 (17.4)11 (5.1)61 (8.4)0.1010.700.696
 Alive 90 days88419 (82.6)203 (94.9)662 (91.6)2.53 (0.84–7.63)0.91 (0.56–1.48)0.91 (0.55–1.49)
 ARDS642 (8.7)13 (6.1)49 (6.8)0.6620.930.929
 No ARDS89621 (91.3)201 (93.9)674 (93.2)1.34 (0.31–5.86)0.98 (0.58–1.54)0.98 (0.58–1.66)
 SS/SSh31314 (60.9)66 (30.8)233 (32.2)0.0030.20.189
 No SS/SSh6479 (39.1)148 (69.2)490 (67.8)3.32 (1.42–7.76)1.19 (0.91–1.56)1.20 (0.91–1.58)
 Sepsis76522 (95.7)165 (77.1)578 (79.9)0.0250.770.764
 No sepsis1951 (4.3)49 (22.9)145 (20.1)5.74 (0.77–42.90)1.05 (0.76–1.45)1.05 (0.76–1.46)
 ICU3389 (39.1)68 (31.8)261 (36.1)0.6900.450.439
 No ICU62214 (60.9)146 (68.2)462 (63.9)1.19 (0.51–2.77)0.90 (0.69–1.18)0.90 (0.68–1.18)
 ICU dead 28 days442 (22.2)5 (7.4)37 (14.2)0.3310.460.451
 ICU alive 28 days2247 (77.8)63 (92.6)224 (85.8)1.95 (0.39–9.71)0.77 (0.38–1.56)0.76 (0.36–1.57)
 ICU dead 90 days622 (22.2)8 (11.8)52 (19.9)0.6720.270.260
 ICU alive 90 days2767 (77.8)60 (88.2)209 (80.1)1.28 (0.26–6.32)0.71 (0.38–1.33)0.69 (0.36–1.32)

Bivariate and multivariate analyses were performed using SPSS (version 15.0; SPSS, Inc., Chicago, IL, USA). The mean±sd age of the patients and controls was 61.8±17.7 and 44.3±19.3 years, respectively; 620 (66%) patients and 435 controls (52%) were male. Genotype distribution of both single-nucleotide polymorphisms did not differ significantly under conditions of Hardy–Weinberg equilibrium in the control group (p=0.444 for rs4957796, p=0.746 for rs62375529). Data are presented as n (%), unless otherwise stated. ARDS: acute respiratory distress syndrome; SS/SSh: severe sepsis/septic shock; ICU: intensive care unit; ICU dead 28/90 days: patients admitted to the ICU who died at 28/90 days; ICU alive 28/90 days: patients admitted to the ICU who survived at 28/90 days #: p-value for the bivariate comparison calculated with the Chi-squared test. : after adjustment for age, sex, comorbidities and admitting hospital, the rs62375529 FER variant remains significantly associated with severe sepsis risk (OR=5.17; 95% CI 1.963–13.68, p=0.001), p-value for the multivariate analysis calculated with binary logistic regression.