Baseline characteristics of 151 patients enrolled in studies of aspiration in COPD
| Aspiration not detected | Aspiration# detected | |
| Subjects n | 121 | 30 |
| Age years (range) | 70.2±5.1 (60.1–80.6) | 72.4±4.3¶ (65.7–78.8) |
| Male/female | 74/47 | 18/12 |
| Body mass index kg·m−2 | 29.4±5.8 | 27.7±6.4 |
| FEV1 % predicted | 49.2±15.3 | 45.3±15.3 |
| FEV1/FVC ratio % | 53.1±13.9 | 51.0±11.1 |
| TLC % predicted | 129.2±22.0 | 129.0±20.5 |
| RV/TLC % | 58.4±8.8 | 60.5±8.2 |
| FENO ppb | 24.5±23.8 | 22.4±22.1 |
| SpO2 % | 95.3±1.8 | 94.7±2.8 |
| Respiratory rate breaths·min−1 | 17.9±4.0 | 18.7±4.7 |
| Comorbidities | ||
| Cardiovascular disease | 99 (82) | 28 (93) |
| Chronic kidney disease | 7 (6) | 1 (3) |
| Gastro-oesophageal reflux disease | 72 (60) | 17 (57) |
| Obstructive sleep apnoea | 20 (17) | 3 (10) |
| Diabetes | 18 (15) | 7 (23) |
| Anxiety–depression | 27 (22) | 8 (27) |
| Medication | ||
| ICS/LABA only | 15 (12) | 2 (7) |
| ICS/LABA/LAMA | 94 (78) | 27 (90) |
| Systemic corticosteroids (long term) | 36 (30) | 12 (40) |
| Antibiotics (long term) | 28 (23) | 7 (23) |
| Oxygen therapy | 21 (17) | 7 (23) |
| Influenza vaccination | 41 (34) | 11 (37) |
| Pneumococcal vaccination | 11 (9) | 4 (13) |
| Antihypertensives | 96 (79) | 26 (87) |
| Antianxiety/antidepressant | 47 (39) | 13 (43) |
| Angiotensin-converting enzyme inhibitors | 26 (22) | 7 (23) |
| Reflux medications | 79 (65) | 17 (57) |
| AQ20 score | 9.6±4.2 | 10.9±3.9 |
| AQ20 score >8 | 79 (65) | 23 (77) |
| EAT-10 score | 2.3±3.9 | 2.9±4.6 |
| OHAT score | 2.2±2.1 | 3.1±2.7 |
| Resting saliva pH | 6.5±0.5 | 6.4±0.7 |
Data are presented as mean±sd or n (%), unless otherwise indicated. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; FENO: exhaled nitric oxide fraction; SpO2: oxygen saturation measured by pulse oximetry; ICS: inhaled corticosteroids; LABA: long-acting beta agonists; LAMA: long-acting muscarinic antagonist; AQ20: Airways Questionnaire-20; EAT-10: Eating Assessment Tool; OHAT: Oral Health Assessment Tool. #: aspiration score of 6–8 on the penetration–aspiration scale [2]; ¶: p≤0.02.