TABLE 4

Indications for random samples of benzodiazepine (BDZ) and opioid prescriptions in oxygen-dependent interstitial lung disease

Overall6 months before starting LTOTLast 6 months of LTOTp-value
Prescriptions3039489860
BDZs
 Known indication
  Pain2 (0.2)1 (0.5)0 (0.0)0.127
  Breathlessness15 (1.4)1 (0.5)10 (2.2)0.127
  Anxiety1009 (96.9)193 (96.5)454 (97.4)0.511
  Other53 (5.1)12 (6.0)29 (6.2)0.913
 Unknown indication387 (27.1)76 (27.5)167 (26.4)0.718
Opioids
 Known indication
  Pain1030 (94.8)284 (98.3)364 (92.4)0.001*
  Breathlessness70 (6.4)4 (1.4)38 (9.6)<0.001*
  Anxiety17 (1.6)0 (0.0)12 (3.1)0.003*
  Other28 (2.6)5 (1.7)12 (3.1)0.276
 Unknown indication524 (32.5)102 (26.1)211 (34.9)0.004*

Data are presented as n or n (%), unless otherwise stated. LTOT: long-term oxygen therapy. Data for “dose” prescriptions before 2012 were excluded as they lacked data on indications in the Prescribed Drug Register. *: p<0.05 (Chi-squared test).