Risk factor analysis for progressive Mycobacterium avium pulmonary disease necessitating multidrug antibiotic treatment within 3 years from initial diagnosis (n=224)
| Characteristic | Univariate analysis | Multivariate analysis | ||
| p-value | OR (95% CI) | p-value | Adjusted OR (95% CI) | |
| PPFE score | 0.576 | |||
| Bronchiectasis score | 0.008 | 1.22 (1.05–1.41) | 0.805 | |
| Cellular bronchiolitis score | 0.018 | 1.22 (1.04–1.45) | 0.182 | |
| Cavity score | <0.001 | 1.50 (1.29–1.74) | 0.278 | |
| Nodule extent score | 0.012 | 1.86 (1.14–3.02) | 0.582 | |
| Consolidation score | <0.001 | 2.98 (1.94–4.60) | <0.001 | 2.74 (1.54–4.85) |
| Radiological type (nodular bronchiectatic) | <0.001 | 0.14 (0.06–0.29) | 0.323 | |
| Causative organisms | ||||
| Mycobacterium avium | 0.981 | |||
| Mycobacterium intracellulare | 0.880 | |||
| Positive sputum AFB smear | <0.001 | 3.81 (2.11–6.88) | 0.026 | 2.33 (1.11–4.89) |
| Age | 0.194 | 0.001 | 0.95 (0.92–0.98) | |
| Sex (female) | 0.518 | 0.324 | ||
| BMI | 0.027 | 0.89 (0.79–0.99) | 0.086 | |
| Smoking pack-years | 0.525 | |||
| Presence of comorbidities | 0.190 | |||
| Previous history of pulmonary TB | 0.723 | |||
| Use of immunosuppressants | 0.817 | |||
PPFE: pleuroparenchymal fibroelastosis; AFB: acid-fast bacilli; BMI: body mass index; TB: tuberculosis.