Predictors for annual decline of forced expiratory volume in 1 s (FEV1) (mL) (ΔFEV1 from maximum lung function (max0–2.5) during the first 2.5 years after diagnosis (after start of therapy) to 12-year follow-up visit) in 12-year follow-up in patients with not-controlled asthma as evaluated by multiple linear regression analysis (n=100)

Unstandardised B coefficient (95% CI)p-value
Age at follow-up−0.10 (−0.53–0.33)0.638
Female12.46 (1.03–23.89)0.033
BMI at follow-up−1.03 (−2.05–0.00)0.049
≥10 pack-years at follow-up−7.92 (−19.01–3.16)0.159
ΔFEV1 mL (baselinemax0–2.5)−0.024 (−0.04–−0.01)0.005
FeNO >20 ppb−23.48 (−35.99–−10.97)<0.001
Average 12-year adherence (<80%) to ICS−10.36 (−20.37–−0.36)0.042

In univariate analysis, unstandardised B coefficient (95% CI) for average 12-year adherence (<80%) to ICS is −11.23 (−22.15–−0.32), p=0.044. BMI: body mass index; FeNO: exhaled nitric oxide fraction; ICS: inhaled corticosteroid.