Lung function change (change in pre-bronchodilator forced expiratory volume in 1 s (ΔFEV1) from maximum lung function (max0–2.5) during the first 2.5 years after diagnosis (after start of therapy) to 12-year follow-up visit) in patients with controlled and not-controlled asthma and different level of adherence (n=181)
| Good adherence ≥80% | Poor adherence <80% | p-value | |
| Not-controlled asthma n | 125 | ||
| ΔFEV1 mL·year–1 | −40 (−56–−20) | −47 (−83–−32) | 0.024 |
| ΔFEV1 % pred·year–1 | −0.47 (−0.98–0.25) | −0.76 (−1.40–−0.17) | 0.029 |
| Controlled asthma n | 56 | ||
| ΔFEV1 mL·year–1 | −39 (−59–−24) | −35 (−67–−25) | 0.859 |
| ΔFEV1 % pred·year–1 | −0.31 (−0.76–0.54) | −0.34 (−1.10–0.07) | 0.271 |
Statistical significances were evaluated by independent-samples Mann–Whitney U-test. When patients with COPD were excluded from the analysis, ΔFEV1 was −36 (−54–−18) mL·year–1 in patients with >80% adherence and −43 (−78–−28) mL·year–1 in patients with <80% adherence and not-controlled asthma (p=0.058).