TABLE 2

Combined cohort adjusted and unadjusted hazard ratios (HRs) for 5-year survival, exacerbation-free survival and cardiac admission-free survival following discharge after index COPD admission according to cardiac biomarker status

	Unadjusted			Adjusted
	Subjects	HR (95% CI)	p-value	Subjects	HR (95% CI)	p-value
Survival	384			337
High troponin T only		0.89 (0.43–1.80)	0.738		0.86 (0.40–1.83)	0.691
High NT-proBNP only		2.13 (1.52–2.99)	<0.001		1.76 (1.18–2.62)	0.005
Both high		2.82 (1.87–4.26)	<0.001		2.28 (1.44–3.60)	<0.001
Exacerbation-free survival	384			337
High troponin T only		1.03 (0.60–1.77)	0.906		0.91 (0.49–1.66)	0.753
High NT-proBNP only		1.17 (0.86–1.58)	0.320		1.10 (0.78–1.54)	0.603
Both high		1.29 (0.88–1.89)	0.196		1.27 (0.83–1.95)	0.277
Cardiac admission-free survival	384			337
High troponin T only		0.87 (0.44–1.70)	0.681		0.74 (0.34–1.57)	0.431
High NT-proBNP only		2.13 (1.54–2.95)	<0.001		1.75 (1.20–2.55)	0.003
Both high		2.55 (1.70–3.84)	<0.001		1.98 (1.25–3.12)	0.003

HR adjusted for CURB65, acidaemia (pH<7.30) and % of predicted forced expiratory volume in 1 s. NT-proBNP: N-terminal pro-B-type natriuretic peptide.