VigiBase data: clinical details of all five reported fatalities with cardioselective β1-blocker use in patients with an adverse drug reaction of asthma or bronchospasm who had evidence of pre-existing asthma
| Report | Year | Cardioselective β1-blockers | Reported adverse drug reactions | |||
| Name | Dose | Duration | Indication | |||
| 1 | 1985 | Metoprolol | Not stated | 1.1 years | Not stated | Asthma (general anaesthetic medications listed) |
| 2 | 2017 | Metoprolol | 100 mg by mouth once daily | Not stated | Hypertension | Asthma, sepsis, pneumonia, emphysema, decreased immune response, renal cancer |
| 3 | 2018 | Acebutolol | 600 mg by mouth once daily | Not stated | Not stated | Asthma, acute MI, cardiogenic shock, metastatic renal cancer |
| 4 | 2009 | Atenolol | 50 mg once daily | Not stated | Not stated | Bronchospasm, acute MI, cardiac failure, aspiration, sudden cardiac death |
| 5 | 2019 | Atenolol | Not stated | 11 years | Hypertension | Asthma, viral pneumonia (immunosuppressant medicines listed) |
MI: myocardial infarction.