Epigenome-wide associations between genome-wide DNA methylation and diffusing capacity of the lung for carbon monoxide (DLCO)/alveolar volume (VA)
| Model | CpG | Chromosome | Position | Gene | RS | FHS | ||||
| Effect estimate | Standard error | FDR | Effect estimate | Standard error | FDR | |||||
| M1 | cg05575921 | 5 | 373 378 | AHRR | 0.065 | 0.012 | 0.017 | 0.037 | 0.0055 | 8.72×10−6 |
| M2 | cg05575921 | 5 | 373 378 | AHRR | 0.064 | 0.012 | 0.047 | 0.040 | 0.0057 | 1.56×10−6 |
| M2 | cg05951221 | 2 | 233 284 402 | ALPG# | 0.049 | 0.0093 | 0.047 | 0.030 | 0.0051 | 3.60×10−4 |
RS: Rotterdam Study (the “discovery panel”); FHS: Framingham Heart Study (the “replication panel”); FDR: false discovery rate; M1: model adjusted for age, sex, current smoking, former smoking, white blood cell count and batch effect; M2: model adjusted for age, sex, current smoking, former smoking, weight, height, white blood cell count and batch effect; #: closest gene (distance >8 Kbp).