General characteristics in the Rotterdam Study (RS) population (the “discovery panel”) and the Framingham Heart Study (FHS) population (the “replication” panel)

RS (n=659)FHS (n=2114)
Age years67.4±5.9065.6±8.38
Female sex369 (56)1159 (55)
Current smokers70 (11)151 (7)
Ex-smokers379 (58)1186 (56)
Weight kg79.9±13.9479.5±17.83
Height cm169.8±9.16167.3±9.54
FEV1 L2.72 (0.71)2.68 (0.75)
% predicted FEV1102.85 (22.82)97.94 (16.94)
FVC L3.56 (0.90)3.68 (0.98)
% predicted FVC108.93 (16.92)101.39 (15.09)
FEV1/FVC %76.65 (7.33)72.89 (6.86)
DLCO# mmol·min−1·kPa−17.81±1.647.47±2.13
DLCO/VA# mmol·min−1·kPa−1·VA−11.52±0.231.42±0.23

Data are presented as mean±sd (for continuous variables) or n (%) (for dichotomous variables). FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; VA: alveolar volume; sd: standard deviation. #: DLCO was corrected for haemoglobin levels in the RS. Interpretable spirometry was available in the RS (n=625) and FHS (n=2114).