TABLE 4

Programmed cell death protein ligand 1 (PD-L1) detection in pleural effusion based on all cases with successful PD-L1 analysis. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio

ParameterPD-L1 expression ≥50% of tumour cells defined as positivePD-L1 expression ≥1% of tumour cells defined as positive
Estimate95% CIEstimate95% CI
Sensitivity %10046–1008656–97
Specificity %6336–844312–80
Positive predictive value %4518–757547–92
Negative predictive value %10066–1006017–93
Positive likelihood ratio2.671.42–5.021.500.76–2.95
Negative likelihood ratio0.00Not defined0.330.07–1.56