TABLE 2

Sarcoidosis involvement of other organs as reported by sarcoidosis patients with hypothyroidism as compared to those with no hypothyroidism#

HypothyroidismNo hypothyroidismp-value
Patients5383284
Multiorgan sarcoidosis ≥3 organs276/532 (52)1444/3154 (46)0.009
Lungs377/492 (77)2201/2909 (76)0.64
Bones or vertebrae43/352 (12)234/2062 (11)0.64
Brain or cranial nerves51/351 (14.5)275/2077 (13)0.51
Peripheral nerves105/387 (27)518/2234 (23)0.09
Central lymph nodes+282/431 (65)1431/2457 (58)0.005
Peripheral lymph nodes§122/391 (31)623/2210 (28)0.23
Eyes138/405 (34)604/2318 (26)0.001
Cardiac59/384 (15)335/2196 (15)0.96
Joints141/408 (35)632/2314 (27)0.003
Kidneys33/350 (9)163/2047 (8)0.36
Parotid or lacrimal glands35/351 (10)130/1985 (6.5)0.02
Stomach/intestines34/360 (9)153/2080 (7)0.17
Liver72/367 (20)312/2125 (15)0.02
Spleen51/356 (14)287/2064 (14)0.83
Muscles39/355 (11)209/2079 (10)0.59
Sinuses45/363 (12)216/2149 (10)0.18
Skin167/412 (40.5)750/2308 (32.5)0.001
Newly arising comorbidities after sarcoid diagnosisƒ
 Probably sarcoid-related274/498 (55)1352/3284 (41)<0.001
 Probably steroid-related284/498 (57)1377/3284 (42)<0.001

Data are presented as n or n/N total (%), unless otherwise stated. #: Patients were asked whether or not the organ involvement is a confirmed diagnosis, suspected or if they were unsure. Prevalence presented in this table is based on confirmed diagnosis only as reported by the patients. For this analysis, answers suspected or “not involved” were regarded as “not involved”. “Unsure” or missing were regarded as missing values. : Multiorgan sarcoidosis defined if three or more organs were involved. +: Lymph nodes in the chest and abdomen. §: Axillary, cervical and inguinal lymph nodes. ƒ: Probably sarcoid-related: cancer, chronic fatigue syndrome, chronic pain syndrome, congestive heart failure, depression, fibromyalgia, lymphoma and sleep disorders; probably steroid-related: diabetes mellitus, cataracts, glaucoma, obesity, hypertension, osteoporosis/osteopenia and sleep apnoea.