TABLE 3

Physical impairment and psychosocial impact of hypothyroidism in patients with sarcoidosis

HypothyroidismNo hypothyroidismAdjusted odds ratio (95% CI)#
Patients n5383284
Psychosomatic impact
 Depression141/489 (29)748/3284 (23)1.3 (1.01–1.6)
 Feeling depressed+167/504 (33)794/2781 (29)1.1 (0.9–1.4)
 Use of antidepressants§204/530 (39)872/3210 (27)1.3 (1.1–1.7)
 Obesity125/489 (26)544/3284 (17)1.7 (1.4–2.1)
 Sleep apnoea132/489 (27)559/3077 (18)1.7 (1.3–2.2)
 Chronic fatigue syndrome138/491 (28)590/3284 (18)1.5 (1.2–2)
 Feeling tired+434/508 (85)2218/2801 (79)1.1 (0.8–1.5)
 Fibromyalgia89/484 (18)325/3284 (10)1.3 (0.97–1.8)
Physical impairment and social impact
 Use of mobility assistive devicesƒ99/538 (18)478/3277 (15)1.1 (0.8–1.4)
 Employment-based disability164/514 (32)747/3207 (23)1.2 (0.95–1.5)
 Missing more than 7 work days in the past year155/280 (55)796/1749 (46)1.2 (1.02–1.6)
 Job termination due to illness159/391 (41)791/2321 (34)1.1 (0.9–1.4)

Data are presented as n or n/N total (%), unless otherwise stated. #: Multivariable logistic regression analysis adjusted for sex, race, age at diagnosis, healthcare insurance status, use of steroids, multiorgan involvement and other sarcoidosis-related comorbidities (cancer, chronic pain syndrome, congestive heart failure and lymphoma). The effective sample size that was kept in the adjusted complete-case analyses was 92% for depression, 81% for “feeling depressed”, 90% for antidepressants use, 92% for obesity, 87% for sleep apnoea, 92% for chronic fatigue syndrome, 82% for “feeling tired”, 92% for fibromyalgia, 92% for “use of mobility device”, 90% for disability, 51% for work days missing and 67% for job termination. : Depression disorder developed after the diagnosis of sarcoidosis as reported by respondents. +: Feeling depressed or feeling tired defined if patient answered feeling tired/depressed often or always. §: Antidepressants reported include citalopram (Celexa), fluoxetine (Prozac), escitalopram (Lexapro), fluvoxamine (Luvox), duloxetine (Cymbalta), venlafaxine (Effexor), paroxetine (Paxil) and sertraline (Zoloft). ƒ: Mobility assistive devices include canes, scooters, walkers and wheelchairs.