Hypothyroidism | No hypothyroidism | Adjusted odds ratio (95% CI)# | |
Patients n | 538 | 3284 | |
Psychosomatic impact | |||
Depression¶ | 141/489 (29) | 748/3284 (23) | 1.3 (1.01–1.6) |
Feeling depressed+ | 167/504 (33) | 794/2781 (29) | 1.1 (0.9–1.4) |
Use of antidepressants§ | 204/530 (39) | 872/3210 (27) | 1.3 (1.1–1.7) |
Obesity | 125/489 (26) | 544/3284 (17) | 1.7 (1.4–2.1) |
Sleep apnoea | 132/489 (27) | 559/3077 (18) | 1.7 (1.3–2.2) |
Chronic fatigue syndrome | 138/491 (28) | 590/3284 (18) | 1.5 (1.2–2) |
Feeling tired+ | 434/508 (85) | 2218/2801 (79) | 1.1 (0.8–1.5) |
Fibromyalgia | 89/484 (18) | 325/3284 (10) | 1.3 (0.97–1.8) |
Physical impairment and social impact | |||
Use of mobility assistive devicesƒ | 99/538 (18) | 478/3277 (15) | 1.1 (0.8–1.4) |
Employment-based disability | 164/514 (32) | 747/3207 (23) | 1.2 (0.95–1.5) |
Missing more than 7 work days in the past year | 155/280 (55) | 796/1749 (46) | 1.2 (1.02–1.6) |
Job termination due to illness | 159/391 (41) | 791/2321 (34) | 1.1 (0.9–1.4) |
Data are presented as n or n/N total (%), unless otherwise stated. #: Multivariable logistic regression analysis adjusted for sex, race, age at diagnosis, healthcare insurance status, use of steroids, multiorgan involvement and other sarcoidosis-related comorbidities (cancer, chronic pain syndrome, congestive heart failure and lymphoma). The effective sample size that was kept in the adjusted complete-case analyses was 92% for depression, 81% for “feeling depressed”, 90% for antidepressants use, 92% for obesity, 87% for sleep apnoea, 92% for chronic fatigue syndrome, 82% for “feeling tired”, 92% for fibromyalgia, 92% for “use of mobility device”, 90% for disability, 51% for work days missing and 67% for job termination. ¶: Depression disorder developed after the diagnosis of sarcoidosis as reported by respondents. +: Feeling depressed or feeling tired defined if patient answered feeling tired/depressed often or always. §: Antidepressants reported include citalopram (Celexa), fluoxetine (Prozac), escitalopram (Lexapro), fluvoxamine (Luvox), duloxetine (Cymbalta), venlafaxine (Effexor), paroxetine (Paxil) and sertraline (Zoloft). ƒ: Mobility assistive devices include canes, scooters, walkers and wheelchairs.