TABLE 4

Medical patients: univariate predictors of hospital mortality

VariableNOR (95% CI)p-value
Age years1671.02 (1.01–1.04)0.005
Female (ref.)1670.914 (0.481–7.738)0.784
PH group1670.704
 1 Pulmonary arterial hypertensionRef.
 2 PH due to left heart disease1.568 (0.303–8.120)0.592
 3 PH due to lung disease/hypoxia1.307 (0.376–4.541)0.674
 4 Chronic thromboembolic PH0.882 (0.359–2.169)0.785
 5 Unclear/multifactorial2.195 (0.656–7.350)0.202
Admission reason#1670.03
 Heart failureRef.Ref.
 Respiratory failure/chest sepsis0.554 (0.254–1.208)0.138
 Sepsis (other)0.356 (0.099–1.277)0.113
 Pulmonary embolism0.800 (0.150–4.274)0.794
 Arrhythmia0.133 (0.028–0.646)0.012
 Renal failure0.267 (0.066–1.079)0.064
 Other0.200 (0.051–0.779)0.020
ISWD1020.998 (0.995–1.001)0.242
APACHE II1371.180 (1.095–1.270)<0.001
Heart rate1661.011 (0.995–1.028)0.190
mSAP mmHg1630.983 (0.964–1.003)0.100
Respiratory rate1671.046 (1.005–1.087)0.026
SpO2 %1670.984 (0.939–1.030)0.482
FiO21655.896 (1.445–24.061)0.013
PaO2 kPa1420.959 (0.888–1.036)0.292
SpO2/FiO2 ratio1340.997 (0.993–1.001)0.114
PaO2/FiO2 ratio1340.983 (0.959–1.008)0.187
Central venous pressure mmHg541.096 (1.021–1.177)0.011
Glasgow Coma Scale1380.727 (0.539–0.980)0.036
pH1480.007 (0.000–0.393)0.016
Base excess mEq·L−11470.933 (0.886–0.984)0.01
Lactate mmol·L−11411.425 (1.117–1.817)0.004
Serum sodium mmol·L−11570.937 (0.884–0.993)0.027
Serum urea mmol·L−115612.7 (4.37–80.2)0.001
Serum creatinine µmol·L−11551.005 (1.001–1.009)0.013
Total bilirubin µmol·L−11436.08 (2.97–19.8)0.022
AST IU·L−11230.999 (0.995–1.002)0.456
CRP mg·L−11411.005 (1.000–1.009)0.054
Haemoglobin g·L−11570.990 (0.978–1.003)0.123
Platelets ×109·L−11560.997 (0.994–1.000)0.033
Right atrial pressure mmHg1091.044 (0.990–1.101)0.108
Mean PAP mmHg1141.005 (0.973–1.037)0.775
PAWP mmHg1021.000 (0.919–1.088)1.000
Cardiac output L·min−11100.909 (0.743–1.112)0.352
Cardiac index L·min−1·m−21040.838 (0.584–1.201)0.335
PVR dyn·s−1·cm−5991.000 (0.999–1.001)0.482
SvO2 %1020.966 (0.929–1.005)0.087

Variables either at most recent review prior to admission (Right heart catheter data, ISWD at 2 weeks to 18 months prior to admission) or at critical care admission (e.g. laboratory tests and physiological observations). Bold indicates statistical significance. PH: pulmonary hypertension; ISWD: incremental shuttle walking distance; APACHE II: Acute Physiology and Chronic Health Evaluation II; mSAP: mean systemic arterial pressure; SpO2: oxygen saturation measured by pulse oximetry; FiO2: inspiratory oxygen fraction; PaO2: arterial oxygen tension; AST: aspartate aminotransferase; CRP: C-reactive protein; PAP: pulmonary artery pressure; PAWP: pulmonary arterial wedge pressure; PVR: pulmonary vascular resistance; SvO2: mixed venous oxygen saturation. #: main indication for critical care admission.