Subject demographics and clinical characteristics
| No NTM pulmonary disease | NTM pulmonary disease | p-value | |
| Subjects | 16 | 8 | |
| Age years# | 27.3 (21.9–37.7) | 25.8 (19.7–32.7) | 0.83 |
| Male | 9 (56.2) | 2 (25) | 0.15 |
| CF genotype | |||
| F508del homozygous | 4 (25) | 3 (37.5) | 0.49 |
| F508del heterozygous | 11 (68.8) | 4 (50) | |
| Other | 1 (6.3) | 1 (12.5) | 0.59 |
| NTM species | |||
| M. avium complex | 9 (56.2) | 6 (75) | 0.81 |
| M. abscessus complex | 4 (25) | 2 (25) | |
| Other | 3 (18.6) | 0 (0) | 0.42 |
| AFB smear positive# | 2 (12.5) | 2 (25) | 0.44 |
| ppFEV1# | 55 (37–69) | 68 (43–80) | 0.41 |
| Disease aggressiveness¶,+ | |||
| Mild | 9 (56.2) | 3 (37.5) | |
| Moderate | 4 (25) | 3 (37.5) | 0.47 |
| Severe | 3 (18.6) | 2 (25) | 0.59 |
| BMI#,+ | |||
| Acceptable | 4 (40) | 1 (33.3) | |
| At risk | 2 (20) | 1 (33.3) | 0.75 |
| Nutritional failure | 4 (40) | 1 (33.3) | 1 |
| CF respiratory cultures# | |||
| P. aeruginosa | 9 (56.2) | 6 (75) | 0.55 |
| S. aureus | 14 (87.5) | 3 (37.5) | 0.01 |
| S. maltophilia | 3 (18.6) | 0 (0) | 0.38 |
| Achromobacter spp. | 2 (12.5) | 1 (12.5) | 1 |
| Burkholderia spp. | 0 (0) | 0 (0) | |
| Aspergillus spp. | 5 (31.3) | 2 (25) | 1 |
| CF respiratory cultures, ≥1 positive¶ | |||
| P. aeruginosa | 10 (62.5) | 6 (75) | 0.57 |
| S. aureus | 16 (100) | 6 (75) | 0.07 |
| S. maltophilia | 3 (18.6) | 1 (12.5) | 1 |
| Achromobacter spp. | 3 (18.6) | 1 (12.5) | 1 |
| Burkholderia spp. | 1 (6.3) | 0 (0) | 1 |
| Aspergillus spp. | 6 (37.5) | 6 (75) | 0.13 |
| Diagnosis of CF-related diabetes¶ | 5 (31.3) | 4 (50) | 0.33 |
| Pulmonary exacerbations¶,+ | 2 (0.75–5) | 2 (1.75–3.75) | 0.88 |
| Use of chronic azithromycin¶ | 9 (56.2) | 5 (62.5) | 1 |
| Use of chronic inhaled antibiotics¶ | 10 (62.5) | 6 (75) | 0.57 |
| Use of inhaled steroids¶ | 10 (62.5) | 8 (100) | 0.04 |
Data are presented as n, median (interquartile range) or n (%), unless otherwise stated. NTM: nontuberculous mycobacteria; CF: cystic fibrosis; M. avium: Mycobacterium avium; M. abscessus: Mycobacterium abscessus; AFB: acid-fast bacilli; ppFEV1: percentage predicted forced expiratory volume in 1 s; BMI: body mass index; P. aeruginosa: Pseudomonas aeruginosa; S. aureus: Staphylococcus aureus; S. maltophilia: Stenotrophomonas maltophilia. #: at incident NTM infection; ¶: within 1 year prior to incident NTM infection; +: details in supplementary methods.