Males | Females | ≥70 years | <70 years | |||||

Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |

Patients n | 728 | 511 | 472 | 767 | ||||

Events n | 53 | 26 | 43 | 36 | ||||

AHI events·h^{−1} | ||||||||

AHI (continuous) | 1.00 (0.97–1.02) | 0.659 | 1.03 (1.00–1.06) | 0.028 | 1.00 (0.98–1.03) | 0.751 | 1.01 (0.98–1.03) | 0.538 |

AHI ≥30 | 0.76 (0.31–1.87) | 0.550 | 4.19 (1.38–12.77) | 0.012 | 1.21 (0.48–3.09) | 0.686 | 1.28 (0.44–3.78) | 0.651 |

ODI events·h^{−1} | ||||||||

ODI (continuous) | 0.99 (0.96–1.01) | 0.357 | 1.04 (1.00–1.07) | 0.032 | 1.00 (0.97–1.03) | 0.933 | 1.00 (0.97–1.03) | 0.972 |

ODI ≥30 | 0.62 (0.22–1.79) | 0.380 | 5.64 (1.78–17.90) | 0.003 | 1.34 (0.53–3.36) | 0.539 | 0.88 (0.20–3.83) | 0.863 |

t_{sat90%} | ||||||||

t_{sat90%} (continuous) | 1.00 (0.99–1.01) | 0.670 | 1.02 (1.00–1.03) | 0.035 | 1.00 (0.99–1.01) | 0.912 | 1.01 (1.00–1.02) | 0.236 |

t_{sat90%} ≥10.4% | 1.28 (0.66–2.46) | 0.467 | 2.57 (1.03–6.41) | 0.043 | 0.91 (0.51–2.11) | 0.913 | 2.43 (1.09–5.42) | 0.030 |

HRs calculated by Cox proportional hazards regression analysis. The multivariable analyses were adjusted for sex, age, body mass index, smoking status, alcohol intake, socioeconomic status and HbA1c. AHI: apnoea–hypopnoea index; ODI: oxygen desaturation index; *t*_{sat90%}: percentage of night-time spent with oxygen saturation <90%.