TABLE 3

Between-group difference for mean absolute changes from baseline at 3- and 6-month follow-up in secondary outcome measures

	*Δ ELVR versus* no-ELVR at 3-month follow-up**	p-value	*Δ ELVR versus* no-ELVR at 6-month follow-up**	p-value
FEV₁ L	0.22±0.05	<0.001	0.21±0.05	<0.001
RV L	−0.81±0.22	<0.001	−0.95±0.21	<0.001
FRC L	−0.55±0.17	0.002	−0.59±0.17	<0.001
TLC L	−0.40±0.14	0.005	−0.39±0.14	0.007
6MWD m	51±18	0.005	58±17	0.001
SGRQ total score	−22±5	<0.001	−18±5	0.001
BODE index score	−2.7±0.4	<0.001	−1.6±0.4	<0.001
mMRC dyspnoea score	−1.4±0.3	<0.0001	−0.7±0.3	0.008

Data are presented as mean±sem (ANCOVA with baseline as covariate). Analyses at 3 months are based on 16 subjects in the no-endoscopic lung volume reduction (no-ELVR) group and 20 subjects in the ELVR group, and at 6 months on 17 subjects in the no-ELVR group and 20 subjects in the ELVR group. FEV₁: forced expiratory volume in 1 s; RV: residual volume; FRC: functional residual capacity; TLC: total lung capacity; 6MWD: 6-min walk distance; SGRQ: St George's Respiratory Questionnaire; BODE: body mass index, airflow obstruction, dyspnoea, exercise capacity; mMRC: modified Medical Research Council.