Differential diagnostic characteristics of type 2 (T2)-low versus T2-high asthma

T2-low asthmaT2-high asthma
SymptomsMostly significantMay be significant
ObesityOften presentMay be present
SmokingOften presentMay be present
Response to inhaled corticosteroidsOften poorUsually good
Severity of asthmaOften difficult to treatMild to severe
Asthma controlOften poorVariable
Sputum eosinophilsAbsentNormal or high levels
Sputum neutrophilsFrequently presentMay be present
Exhaled nitric oxideUsually normalElevated or normal
AirwaysOften presentMay be present