Correlation of extracellular matrix proteins (collagen-1 and fibronectin) with lung function and small airway lamina propria thickness
| NLFS | COPD-CS | COPD-ES | |
| Collagen-1 in lamina propria area versus lung function (FEV1/FVC) | r′=−0.64 p<0.05 | r′=0.35 p-value ns | |
| Fibronectin in lamina propria area versus lung function (FEV1/FVC) | r′=0.35 p-value ns | r′=0.007 p-value ns | |
| Collagen-1 in lamina propria area versus airway wall lamina propria thickness (μm) | r′=0.05 p-value ns | r′=0.59 p<0.05 | r′=0.37 p<0.05 |
| Fibronectin in lamina propria area versus airway wall lamina propria thickness (μm) | r′=0.4 p-value ns | r′=−0.01 p-value ns | r′=−0.01 p-value ns |
NLFS: normal lung function smoker; COPD-CS: COPD current smoker; COPD-ES: COPD ex-smoker; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; r′: Spearman's r; ns: nonsignificant.