Changes in pulmonary function, 6-min walk test and quality of life
| Time after infusion | ||||||
| 1 month | 2 months | 3 months | 6 months | 9 months | 12 months | |
| Subjects | 13 | 11 | 13 | 10 | 7 | 6 |
| ΔFVC mL | −93±240 | −184±272# | −212±275# | −200±240# | −214±292 | −212±189# |
| ΔFVC % change | −3.7±10.8 | −6.8±12.7 | −8.1±11.7 | −7.7±10.5 | −7.0±10.5 | −7.6±6.4 |
| ΔTLC mL | 27±267 | −79±187 | −151±315 | −169±370 | −260±338 | −345±374 |
| ΔTLC % change | 0.5±4.1 | −1.3±2.9 | −2.3±4.9 | −2.7±5.9 | −4.3±5.0 | −5.5±5.5 |
| ΔDLCO mL·mmHg−1·min−1 | −0.2±1.3 | −0.2±1.7 | −1.1±1.7# | −0.9±1.9 | −1.2±2.3 n=6 | −1.5±2.6 |
| ΔDLCO % | −1.7±11.1 | −2.6±11.6 | −9.5±14.2 | −8.3±14.3 | −12.1±16.8 n=6 | −11.5±19.5 |
| Δ6MWD m | 5.3±32.4 | 9.0±34.6 | 1.8±71.4 | −9.8±37.3 | −40.0±83.1 | −16.7±41.3 |
| Patients with FVC decline <10% | 11 | 7 | 7 | 6 | 4 | 4 |
| Patients with DLCO decline <15% | 12 | 10 | 8 | 7 | 2 | 4 |
| ΔSGRQ symptoms | 6.0±14.3 | 4.9±16.6 | 5.6±19.9 | 3.1±16.4 | 10.8±30.8 | 3.6±27.6 |
| ΔSGRQ activity | 3.7±16.7 | −1.4±20.2 | −0.8±23.2 | −3.8±27.1 | 7.0±27.9 | 3.8±28.6 |
| ΔSGRQ impact | −0.5±11.3 | −0.7±10.8 | 0±16.0 | 1.6±13.0 | 6.0±20.8 | −2.9±15.3 |
| ΔSGRQ total | 0.7±11.2 | −0.8±12.6 | −0.5±16.2 | −0.5±15.7 | 5.2±19.8 | −2.0±17.6 |
Data are presented as n or mean±sd. FVC: forced vital capacity; TLC: total lung capacity; DLCO: diffusing capacity of the lung for carbon monoxide; 6MWD: 6-min walk distance; SGRQ: St George's Respiratory Questionnaire. #: significant change compared to baseline values, p<0.05.