TABLE 3

Discriminant operational taxonomic unit (OTU) for cases during acute lower respiratory tract infection and after 4–8 weeks follow-up compared to controls

AssociationOTUCases at admission versus controlsCases at recovery versus controls
FCSignificant withinFCSignificant within
AdmissionLactococcus lactis (67)2.06ms+Vnsns
Corynebacteriaceae (161)1.83ms+Vnsns
Abiotrophia (111)1.66ms+Vnsns
Corynebacterium (62)1.64msnsns
Megasphaera (137)1.62msnsns
Fusobacterium (74)1.61msnsns
Actinomyces (48)1.56msnsns
Fusobacterium (83)1.53msnsns
Actinomyces graevenitzii (68)1.52ms+Vnsns
Acinetobacter soli (125)1.51msnsns
Actinomyces johnsonii (75)1.51msnsns
Dolosigranulum pigrum (5)0.43msnsns
Dolosigranulum (122)0.4ms+Vnsns
Admission and recoveryHaemophilus influenzae/haemolyticus (2)3.85ms+V1.69V
Neisseria lactamica (19)2.22ms+V1.96ms+V
Prevotella oris (45)2.03ms1.72ms+V
Moraxella (54)0.32ms+V0.45ms+V
Moraxella (58)0.19ms+V0.45ms+V
Moraxella lincolnii (6)0.18ms+V0.3ms+V
Moraxella (84)0.17ms+V0.34ms
Moraxella (163)0.15ms+V0.39ms+V
Moraxella (112)0.08ms1.68ms
Helcococcus (43)0.07ms0.07ms+V
RecoveryNeisseriaceae (15)nsns2.26ms+V
Moraxella (12)nsns1.83ms
Porphyromonas (39)nsns1.62ms
Bradyrhizobium (17)nsns1.54ms+V
Janthinobacterium lividum (23)nsns0.09ms+V

FC: fold change; ms: metagenomeSeq analysis; V: VSURF analysis; ns: not significantly different.