Baseline characteristics of patients
| Low dose (10×106 MSCs) | Intermediate dose (50×106 MSCs) | High dose (100×106 MSCs) | Total | |
| Subjects | 3 | 3 | 7 | 13 |
| Age years | 60.5 (54.4–68.0) | 65.6 (64.3–78.0) | 70.2 (66.1–78.0) | 68.0 (64.3–77.2) |
| Male/female | 3/0 | 3/0 | 6/1 | 12/1 |
| Time since IPF symptoms years | 4.1±1.7 | 3.5±3.7 | 3.0±1.6 | 3.3±2.1 |
| Time since IPF diagnosis years | 1.9±2.1 | 3.5±4.0 | 1.6±1.7 | 2.1±2.4 |
| Current or former smoker | 3 (100) | 2 (66.67) | 5 (71.43) | 10 (76.9) |
| Smoking pack-years | 19.7±4.5 | 20.0±0 | 22.5±22.1 | 21.0±13.8 |
| BMI kg·m−2 | 27.7±1.9 | 29.4±1.0 | 26.3±2.7 | 27.4±2.5 |
| Baseline SpO2 | 96.0±2.6 | 94.7±0.6 | 95.3±1.6 | 95.3±1.7 |
| MRC dyspnoea scale 0/1/2/3 | 1/1/0/1 | 1/2/0/0 | 0/6/1/0 | 2/9/1/1 |
| Cough intensity 0/1/2/3 | 0/0/2/1 | 0/1/2/0 | 1/3/1/2 | 1/4/5/3 |
| Cough frequency | 5 (5–7) | 3 (2–4) | 3 (2–4) | 3 (2–5) |
| SGRQ symptoms | 39.4 (23.8–50.7) | 21.2 (0–39.0) | 30.5 (23.8–36.9) | 30.5 (23.8–39.0) |
| SGRQ activity | 67.2 (0–73.0) | 67.1 (35.5–73.8) | 48.3 (41.5–67.1) | 48.5 (41.5–67.2) |
| SGRQ impact | 49.7 (0–50.1) | 24.1 (11.6–36.0) | 15.3 (10.3–30.6) | 16.0 (11.6–36.0) |
| SGRQ total | 53.3 (4.0–57.1) | 37.8 (20.5–49.0) | 24.2 (23.2–44.1) | 28.9 (23.2–49.0) |
| Baseline PaO2 mmHg | 76.7±14.2 | 72.7±4.7 | 68.0±4.1 | 71.3±7.9 |
| FVC % pred | 83.7±36.5 | 69.4±15.6 | 74.9±15.8 | 75.6±20.3 |
| FEV1 % pred | 82.3±33.3 | 75.2±12.0 | 77.1±16.7 | 77.9±18.9 |
| FEV1/FVC % | 78.7±2.1 | 84.0±7.5 | 80.1±7.3 | 80.7±6.4 |
| TLC % pred | 66.0±25.2 | 58.5±9.0 | 60.9±9.8 | 61.5±13.2 |
| DLCO adj % pred | 45.7±18.5 | 57.0±18.7 | 43.1±5.7 | 46.9±12.9 |
| 6MWD m | 476.0±114.5 | 491.0±56.7 | 491.9±63.6 | 488±69.2 |
| 6MWT SpO2 nadir | 87.0±8.9 | 88.0±1.7 | 77.9±6.8 | 82.3±7.9 |
| HRCT findings | ||||
| Traction bronchiectasis | 3 | 3 | 6 | 12 |
| Reticular pattern | 3 | 3 | 7 | 13 |
| Honeycombing | 1 | 2 | 7 | 10 |
| Pulmonary biopsy | 2 (66.67) | 2 (100) | 1 (14.29) | 5 (38.5) |
Data are presented as n, median (interquartile range), mean±sd or n (%). MSCs: mesenchymal stromal cells; IPF: idiopathic pulmonary fibrosis; BMI: body mass index; SpO2: peripheral oxygen saturation; MRC: Medical Research Council; SGRQ: St George's Respiratory Questionnaire; PaO2: arterial oxygen tension; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; TLC: total lung capacity; DLCO: diffusing capacity of the lung for carbon monoxide; 6MWD: 6-min walk distance; 6MWT: 6-min walk test; HRCT: high-resolution computed tomography.