TABLE 3

Multiple linear Cox regression including either sputum eosinophils or PRISE #1

	Hazard ratio (95% CI)	p-value	Generalised R²
Sputum eosinophils
History of exacerbations	1.40 (0.97–2.03)	0.071	0.377
Sex (male)	0.33 (0.13–0.85)	0.022*
Season of ICS withdrawal (not in November, December, or January^#)	0.36 (0.15–0.88)	0.025*
Pack-years smoking ≥38^¶	0.70 (0.3301.46)	0.337
Sputum eosinophils ≥3%⁺	2.24 (1.09–4.58)	0.027*
PRISE #1
History of exacerbations	1.53 (1.03–2.28)	0.035	0.495
Sex (male)	0.47 (0.17–1.28)	0.14
Season of ICS withdrawal (not in November, December, or January^#)	0.27 (0.10–0.69)	0.006*
Pack-years smoking ≥38^¶	0.50 (0.22–1.15)	0.105
PRISE #1 (ES stratified by tertiles)
Second tertile (N=13)	2.59 (1.11–6.05)	0.027*
Third tertile (N=15)	5.35 (2.12–13.47)	<0.001*

ICS: inhaled corticosteroid; ES: enrichment score. ^#: dichotomised as “outside” versus “in” the period; ^¶: dichotomised using the median value at baseline; ⁺: dichotomised as ≥3% (N=15) or <3% (N=28). *: p<0.05.