TABLE 2

Monovariate Cox regression hazard ratios

	Hazard ratio (95% CI)	p-value	Generalised R²
History of exacerbations	1.5 (1–2.1)	0.046*	0.08
Season of ICS withdrawal (not in November, December or January^#)	0.3 (0.13–0.68)	0.004*	0.152
Sex (male)	0.31 (0.13–0.78)	0.012*	0.12
Smoking status (current smoker)	0.68 (0.36–1.30)	0.24	0.03
Pack-years smoking ≥38^¶	0.49 (0.25–0.96)	0.038*	0.095
Sputum eosinophils ≥3%⁺	2.3 (1.1–4.6)	0.021*	0.11
% Sputum eosinophils (stratified by tertiles)
Second tertile (N=15)	1.4 (0.62–3.2)	0.42	0.124
Third tertile (N=15)	2.8 (1.17–6.5)	0.02*
PRISE #1 (ES stratified by tertiles)
Second tertile^§ (N=13)	2.3 (0.99–5.2)	0.052	0.202
Third tertile^§ (N=15)	3.7 (1.57–8.5)	0.003*

ICS: inhaled corticosteroid; ES: enrichment score. ^#: dichotomised as “outside” versus “in” the period; ^¶: dichotomised using the median value at baseline; ⁺: dichotomised ≥3% (N=15), <3% (N=28). ^§: compared to the first tertile. *: p<0.05.