TABLE 1

Characteristics of study participants, stratified by exacerbation status

Asthma subjects without exacerbationsAsthma subjects with exacerbations
Subjects n336427
Females n (%)226 (67.3)302 (70.7)
Age years60.85±8.4361.67±8.21
BMI28.20±4.6128.25±4.79
Smoking status n (%)
 Never105 (31.5)156 (36.6)
 Former188 (56.5)213 (50.0)
 Current40 (12.0)57 (13.4)
Total follow-up years11.98±6.0814.69±6.22
Follow-up years with asthma10.74±5.5913.09±5.83
Asthma onset age years, median (IQR)55.53 (45.25, 64.63)58.17 (45.71, 67.20)
Asthma onset >40 years n (%)274 (81.5)341 (79.9)
Total number exacerbations4.48±5.59
Exacerbation rate0.40±0.53
GINA class n (%)
 014 (4.17)0.01 (4)
 161 (18.2)2.81 (12)
 271 (21.1)9.13 (39)
 3120 (35.7)30.0 (128)
 4+570 (20.8)57.1 (244)
Blood eosinophils 103 µL−10.25±0.130.28±0.19
Hypertension n (%)142 (53.2)171 (49.4)
Coronary heart disease n (%)13 (3.9)20 (4.7)
Diabetes mellitus n (%)38 (11.3)39 (9.1)
Depressive symptoms n (%)37 (15.5)54 (20.9)
Osteoporosis n (%)9 (3.3)18 (5.2)

Data are presented as mean±sd, unless otherwise stated. BMI: body mass index; GINA: Global Initiative for Asthma. Baseline characteristics of study participants stratified by exacerbation status. Data were missing in: BMI (n=61), smoking status (n=14), eosinophils (n=285), hypertension (n=12), depressive symptoms (n=278) and osteoporosis (n=151).