Total on- and post-treatment cause-specific mortality by body mass index (BMI) category
| Underweight <20 kg·m−2 | Normal 20– <25 kg·m−2 | Overweight 25– <30 kg·m−2 | Class I obesity 30– <35 kg·m−2 | Class II obesity 35– <40 kg·m−2 | Class III obesity ≥40 kg·m−2 | |
| Subjects n | 1111 | 4306 | 5662 | 3452 | 1367 | 587 |
| Respiratory mortality | ||||||
| Deaths (%) | 24 (2.2%) | 49 (1.1%) | 27 (0.5%) | 23 (0.7%) | 8 (0.6%) | 6 (1.0%) |
| Hazard ratio (95% CI) | 1.44 (0.86–2.41) | Ref. | 0.51 (0.32–0.81) | 0.77 (0.46–1.30) | 0.80 (0.37–1.72) | 1.31 (0.54–3.16) |
| Cardiovascular mortality | ||||||
| Deaths (%) | 41 (3.7%) | 132 (3.1%) | 119 (2.1%) | 94 (2.7%) | 35 (2.6%) | 24 (4.1%) |
| Hazard ratio (95% CI) | 1.30 (0.90–1.87) | Ref. | 0.69 (0.53–0.88) | 0.90 (0.68–1.19) | 1.04 (0.71–1.53) | 1.87 (1.19–2.94) |
Hazard ratio (95% CI) per Cox proportional hazards. Adjusted model accounts for age, sex, region, race, ischaemic heart disease indicator, vascular disease indicator, smoking status, cardiovascular entry criteria (history and risk by age), previous COPD exacerbations, % predicted forced expiratory volume in 1 s, treatment arm and BMI.