Sample size calculation for within and between visit (V) study designs
| Change in LCI | Within visit limits of agreement (V2-V1) | Between visit limits of agreement (V3-V1) | ||
| 80% power | 90% power | 80% power | 90% power | |
| 2.4 | 15 | 19 | 12 | 16 |
| 2.6 | 12 | 16 | 10 | 13 |
| 2.8 | 11 | 14 | 9 | 12 |
| 3.0 | 9 | 12 | 8 | 10 |
Estimated sample size calculation using an absolute change in lung clearance index (LCI)1/40th and the within- and between-visit limits of agreement at 80% and 90% power.