TABLE 2

Markers of inflammation between groups

High upper airway symptomsLow upper airway symptomsOdds ratio (95% CI)p-value
Subjects n74106
C-reactive protein mg·L−12.9 (1.8–4.8)2.9 (1.9–6.4)0.330
Blood eosinophils (n=180)
 % of total leukocytes3.0 (1.6–4.1)2.3 (1.4–3.1)<0.05
 actual number, 109·L−10.20 (0.11–0.33)0.20 (0.10–0.21)<0.05
 n (%) patients with ≥0.30×109·L−130 (41)19 (18)3.1 (1.6–6.2)<0.001
 n (%) patients with ≥3%36 (49)30 (29)2.4 (1.3–4.5)<0.01
Sputum (n=87)
 Eosinophils, % of total1.8 (0.3–6.3)0.5 (0–1.7)<0.05
 n (%) patients with ≥3%12 (40)11 (21)2.5 (0.9–6.7)0.067
 Neutrophils, % of total57±26%63±310.314
 Macrophages, % of total29 (15–49)21 (5–45)0.221
 Lymphocytes, % of total0.13 (0–0.59)0 (0–0.19)<0.05

​​​​​​​Data presented as the median and interquartile range, mean±sd, or count and percentage. Between-group comparisons calculated with either Mann–Whitney U test or t-test for continuous data or Chi-square test for categorical data. Odds ratios are unadjusted.