Unadjusted and adjusted associations with undernutrition in children and adults in the South Africa Cystic Fibrosis Registry, 2018
| Undernutrition# (n=398) | |||||
| Univariable analysis¶ | Multivariable analysis (n=190) | ||||
| n | Unadjusted OR (95% CI) | p-value | Adjusted OR (95% CI) | p-value | |
| WAZ ≤1.0 at diagnosis (ref: ≥−1) | 270 | 2.18 (1.07–4.44) | 0.024* | Excluded to preserve n due to large % missing | |
| Current age (unit: 10 years) | 398 | 0.82 (0.66–1.01) | 0.062 | 0.96 (0.76–1.21) | 0.698 |
| P.Phe508del (ref neither record) | |||||
| Homozygous | 398 | 0.50 (0.27–0.92) | 0.043 | NS | |
| Heterozygous | 398 | 0.85 (0.46–1.58) | |||
| 3120+1G>A hetero/homozygous | 398 | 2.55 (1.42–4.58) | 0.002* | 1.32 (0.66–2.68) | 0.438 |
| Caucasian (ref: other ancestry) | 398 | 0.35 (0.22–0.57) | <0.001* | 0.56 (0.28–1.12) | 0.100 |
| Receiving social welfare grant (ref: no) | 398 | 2.99 (1.70–5.25) | <0.001* | 1.81 (0.92–3.57) | 0.088 |
| Private health insurance (ref: no) | 398 | 0.46 (0.28–0.73) | <0.001* | 0.87 (0.46–1.63) | 0.661 |
| Ever had MRSA (ref: no) | 351 | 1.86 (0.80–4.35) | 0.165 | NS | |
| Chronic MRSA (ref: no) | 255 | 2.31 (0.77–6.94) | 0.145 | NS | |
| Chronic P. aeruginosa (ref: no) | 256 | 1.76 (1.00–3.12) | 0.050 | NS | |
NS: nonsignificant; WAZ: weight-for-age; MRSA: methicillin-resistant S. aureus; WHZ: weight-for-height z-score; BMIZ: body mass index z-score. #Undernutrition includes: WHZ ≤1.0, <2 years age; BMIZ ≤1.0, 2–17 years; or BMI<18.5 kg·m−2, ≥18 years. ¶All variables with unadjusted p-values <0.2 in the univariable analyses are tabulated. Refer to supplementary table S4 for full set of univariable results. *Unadjusted p-values are shown; indicated variables had adjusted p-values<0.2 using Holm's method and were thus included in the multivariable regression model.