TABLE 5

Summary of GSK2798745 pharmacokinetic parameters

ParameterVisit#NnGeometric mean95% CI (lower, upper)%CVb
Cmax ng·mL−1Day 1161617.862(14.468–22.052)41.1
Day 71510.959(9.425–12.741)27.7
AUC(0–3.5) h·ng·mL−1Day 1161636.156(28.328–46.148)48.3
Day 71526.151(22.479–30.424)27.8
C24 ng·mL−1Day 716152.4179(1.7295–3.3803)66.5
Tmax h+Day 116162.500(1.00–3.50)NA
Day 7152.500(1.00–3.50)NA

AUC: area under the curve. #: day 1 dose 4.8 mg; Days 2–7 dose 2.4 mg. : coefficient of variability between participants. +: Tmax expressed as median and range.