Parameter | Visit# | N | n | Geometric mean | 95% CI (lower, upper) | %CVb¶ |
Cmax ng·mL−1 | Day 1 | 16 | 16 | 17.862 | (14.468–22.052) | 41.1 |
Day 7 | 15 | 10.959 | (9.425–12.741) | 27.7 | ||
AUC(0–3.5) h·ng·mL−1 | Day 1 | 16 | 16 | 36.156 | (28.328–46.148) | 48.3 |
Day 7 | 15 | 26.151 | (22.479–30.424) | 27.8 | ||
C24 ng·mL−1 | Day 7 | 16 | 15 | 2.4179 | (1.7295–3.3803) | 66.5 |
Tmax h+ | Day 1 | 16 | 16 | 2.500 | (1.00–3.50) | NA |
Day 7 | 15 | 2.500 | (1.00–3.50) | NA |
AUC: area under the curve. #: day 1 dose 4.8 mg; Days 2–7 dose 2.4 mg. ¶: coefficient of variability between participants. +: Tmax expressed as median and range.