Performance of Kit-LPA and LPA versus MGIT-DST for the detection of MDR-TB and XDR-TB
| Kit-LPA versus MGIT-DST | LPA versus MGIT-DST | ||||||
| Drug# (n)¶ | Sensitivity % (95% CI)+ | Specificity % (95% CI) | Concordance % (κ)§ | Drug# | Sensitivity % (95% CI) | Specificity % (95% CI) | Concordance % (κ) |
| RIF (n=130) | 83.3 (52–98) | 96.6 (91–99) | 95.3 (0.74) | RIF (n=128) | 83.3 (52–98) | 97.4 (93–99) | 96.1 (0.77) |
| INH (n=130) | 77.7 (52–94) | 93.7 (87–97) | 91.5 (0.67) | INH (n=128) | 83.3 (59–96) | 94.5 (88–99) | 91.5 (0.73) |
| FLQ (n=122) | 85.7 (42–100) | 95.7 (90–99) | 95.1 (0.64) | FLQ (n=124) | 85.7 (42–100) | 95.7 (90–99) | 95.1 (0.64) |
| AMN (n=122) | 66.6 (9–99) | 99.1 (95–100) | 98.3 (0.66) | AMN (n=124) | 66.6 (9–99) | 100 (97–100) | 99.2 (0.79) |
Kit-LPA: Kit-extracted DNA with line probe assay; LPA: line probe assay; MGIT-DST: Mycobacteria Growth Indicator Tube–drug susceptibility testing; MDR-TB: multidrug-resistant TB; XDR-TB: extensively drug-resistant TB. #RIF: rifampicin; INH: isoniazid; FLQ: fluoroquinolones; AMN: aminoglycosides. ¶The details of samples are provided in supplementary figures S2 and S3. +CI: confidence interval. §κ: Cohen's kappa coefficient.