TABLE 2

Intraclass correlation coefficients for within and between visit measures of the lung clearance index

Mean±sd V1Mean±sd V2Within visit ICC 20minMean±sd V3 (between visit)Between visit ICC 8weeks
FEV11.36±0.471.42±0.461.35±0.430.92
FEV1 %51.45±14.8652.94±16.7152.94±16.710.92
FEF25–750.58±0.360.62±0.260.62±0.260.64
FVC L2.58±0.632.86±0.732.57±0.550.74
LCI1/40th11.24±2.2511.11±1.900.9211.42±2.030.88
FRC1/40th L3.51±1.113.19±0.930.963.50±0.890.92
Scond0.06±0.110.06±0.150.940.04±0.030.52
Sacin0.784±0.460.84±0.590.950.698±0.400.80
LCIds1.29±0.361.27±0.210.471.43±0.380.05
LCIvent1.54±0.311.50±0.250.801.51±0.200.10
LCI1/20th8.59±1.438.40±1.270.968.53±1.180.80
FRC1/20th L3.40±1.053.55±1.010.903.38±1.010.91

n=19. Intraclass correlation coefficient (ICC) measured by Pearson's correlation coefficient. FEV1: forced expiratory volume in 1 s; FEF25–75: forced expiratory flow at at 25–75% of FVC; FVC: forced vital capacity; LCI: lung clearance index; FRC: functional residual capacity; Scond: convection-dependent ventilation heterogeneity, Sacin: diffusion-convection-dependent ventilation heterogeneity. 1/40th=FRC or LCI calculated at traditional stopping point. 1/20th=FRC or LCI calculated at truncated stopping point of 1/20th of the end tidal wash-in concentration over three consecutive breaths.