TABLE 4

Odds ratios with 95% confidence intervals of alive or at home 1-year after surgery, and hazard ratios (HRs) with 95% confidence intervals of recurrence risk and mortality of common risk factors and stair-climbing test for lung cancer adjusted for confounding factors

VariableNot alive or not at home 1year after surgery OR (95% CI)Lung-cancer-specific mortality HR (95% CI)Non-cancer-specific mortality HR (95% CI)Overall mortality HR (95% CI)
Stair climbing <11  m versus >12 m, adjusted#3.82 (1.28–11.4)1.25 (0.55–2.85)4.28 (2.10–8.73)2.38 (1.43–3.98)
Age at surgery >80 years versus <80 years, adjusted#9.82 (2.31–41.8)1.08 (0.28–4.11)3.38 (1.20–9.48)1.97 (0.89–4.35)
Male sex versus female, adjusted#0.54 (0.18–1.66)1.11 (0.51–2.43)2.86 (1.27–6.45)1.76 (1.01–3.07)
Former smoker versus never, adjusted#NA1.99 (0.53–7.50)1.73 (0.61–4.87)1.82 (0.82–4.06)
Current smoker versus never, adjusted#NA2.21 (0.56–8.78)1.43 (0.50–4.12)1.65 (0.72–3.81)
Charlson comorbidity index ≥5 versus <5 points, adjusted#5.57 (1.38–22.6)2.90 (0.90–9.35)3.40 (1.21–9.54)2.79 (1.32–5.90)
ppoFEV1 ≤50% versus >50%, adjusted#1.81 (0.55–5.98)0.86 (0.34–2.16)1.65 (0.70–3.87)1.14 (0.62–2.10)
ppoDLCO ≤50% versus >50%, adjusted#4.33 (1.27–14.8)0.96 (0.37–2.48)1.81 (0.79–4.14)1.43 (0.78–2.63)
Adenocarcinoma versus squamous cell cancer, adjusted#1.35 (0.41–4.47)1.54 (0.63–3.74)1.69 (0.78–3.67)1.50 (0.85–2.63)
Stage II versus stage I, adjusted#2.50 (0.62–9.98)3.27 (1.23–8.68)1.27 (0.57–2.81)1.66 (0.92–3.02)
Stage III versus stage I, adjusted#8.18 (1.53–43.7)5.75 (1.75–18.9)0.44 (0.08–2.31)2.04 (0.89–4.70)

ppo: predicted post-operative; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide. #: adjustment for age, sex, tobacco use, Charlson comorbidity index, ppoFEV1, ppoDLCO, histological type, stage, neo- or adjuvant treatment, and stair-climbing group (<11 and >12 m). Statistically significant values are highlighted in bold.