Patient characteristics and response to antibody therapy
| All | Ex-smokers | Nonsmokers | p-value | |
| Patients | 158 | 48 (30) | 110 (70) | |
| Females | 102 (65) | 21 (44) | 81 (74) | 0.010* |
| Age, years | 53.4±14.67 | 58.88±11.40 | 51.07±15.33 | 0.002* |
| BMI, kg·m−2 | 28.56±6.41 | 28.90±4.89 | 28.41±6.99 | 0.060 |
| Duration of the disease, years | 26.47±16.33 | 24.42±18.65 | 26.94±15.30 | 0.045* |
| Smoking pack-years | 21.70±18.07 | 27.98±17.4 | 4.94±1.83 | <0.001* |
| Comorbidities | ||||
| COPD | 36 (33) | 24 (50) | 12 (11) | <0.001* |
| Emphysema | 19 (12) | 10 (21) | 9 (8) | 0.017* |
| Allergy | 92 (84) | 27 (56) | 66 (60) | 0.331 |
| Atopic dermatitis | 18 (16) | 3 (6) | 15 (14) | 0.095 |
| Chronic sinusitis/nasal polyps | 70 (64) | 17 (35) | 53 (48) | 0.078 |
| Obstructive sleep apnoea | 16 (15) | 8 (17) | 8 (7) | 0.287 |
| Gastro-oesophageal reflux | 11 (10) | 3 (6) | 8 (7) | 0.891 |
| Obesity# | 17 (15) | 3 (6) | 14 (13) | 0.107 |
| ACT score | ||||
| At baseline | 12.87±5.45 | 10.78±4.02 | 12.11±4.76 | 0.353 |
| At follow-up | 16.50±5.88 | 16.13±6.03 | 16.66±5.83 | 0.568 |
| Δ pre- to post-treatment | 4.07±5.71 | 4.60±6.08 | 3.83±5.55 | 0.423 |
| FEV1, L | ||||
| At baseline | 1.97±0.80 | 1.66±0.60 | 2.10±0.84 | 0.007* |
| At follow-up | 2.11±0.77 | 1.86±0.68 | 2.21±0.80 | 0.263 |
| Δ pre- to post-treatment | 0.14±0.42 | 0.21±0.36 | 0.12±0.46 | 0.538 |
| Exacerbation rate | ||||
| At baseline | 4.08±4.16 | 4.90±4.05 | 3.73±4.17 | 0.598 |
| At follow-up | 0.22±0.63 | 0.25±0.94 | 0.21±0.43 | 0.240 |
| Δ pre- to post-treatment | −3.89±4.12 | −4.79±4.14 | −3.49±4.06 | 0.518 |
| Regular oral corticosteroid dose, mg·day−1 | ||||
| At baseline | 7.15± 8.32 | 8.33±7.45 | 6.62±8.67 | 0.700 |
| At follow-up | 2.35±4.76 | 3.50±5.48 | 1.84±4.33 | 0.170 |
| Δ pre- to post-treatment | −3.91±8.74 | −3.79±10.35 | −3.97±7.97 | 0.200 |
Data are presented as n, n (%) or mean±sd, unless otherwise stated. BMI: body mass index; ACT: Asthma Control Test; FEV1: forced expiratory volume in 1 s. #: BMI >30 kg·m−2. *: significant p-value, p<0.05.